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About This Item
经验公式(希尔记法):
C12H16F3N · HCl
CAS号:
分子量:
267.72
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
推荐产品
药品控制
USDEA Schedule IV
SMILES字符串
Cl.CCN[C@H](C)Cc1cccc(c1)C(F)(F)F
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m1./s1
InChI key
ZXKXJHAOUFHNAS-SBSPUUFOSA-N
生化/生理作用
活性较低的对映体
Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
警示用语:
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
Recent studies in the clinical pharmacology of anorectic drugs.
Silverstone, et al.
Recent Adv. Obes. Res., 5, 285-285 (1986)
Enhanced behavioral response to serotonin-related agonists in postweaning protein malnourished mice.
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Nicolas Deltour et al.
Pharmacoepidemiology and drug safety, 21(6), 584-585 (2012-04-21)
Geneviève Derumeaux et al.
PloS one, 7(6), e38273-e38273 (2012-06-23)
REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. Double-blind, parallel-group, international, randomised, non-inferiority trial. More than half of the 196 participating centres were primary care centres. Patients
Can benfluorex induce congenital malformations?
I Lacroix et al.
Diabetes & metabolism, 38(4), 373-374 (2012-05-09)
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