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F0503

Sigma-Aldrich

5-氟-2′-脱氧尿嘧啶核苷

thymidylate synthase inhibitor

别名:

2′-脱氧-5-氟脲苷, FUDR, 氟脲苷

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500 MG
¥1,861.34

¥1,861.34

国内现货，预计发货时间2025年4月23日详情

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500 MG
¥1,861.34

About This Item

经验公式（希尔记法）:
C9H11FN2O5
CAS号:
50-91-9
分子量:
246.19
Beilstein:
90221
EC 号:
200-072-5
MDL编号:
MFCD00006530
UNSPSC代码:
12352202
PubChem化学物质编号:
24894724
NACRES:
NA.77

¥1,861.34

国内现货，预计发货时间2025年4月23日详情

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生物来源

synthetic (organic)

质量水平

200

方案

≥99% (HPLC)

表单

powder

mp

148 °C (lit.)

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

储存温度

room temp

SMILES字符串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

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32029341620803071
Dimethyl sulfate ≥99.5%

D186309

Dimethyl sulfate

Dimethyl sulfate ≥99%

320293

Dimethyl sulfate

Dimethyl sulfate purum, ≥95.0% (GC)

41620

Dimethyl sulfate

Dimethyl sulfate for synthesis

803071

Dimethyl sulfate

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

bp

188 °C (lit.)

bp

188 °C (lit.)

bp

188 °C (lit.)

bp

188.5 °C/1013 hPa (decomposition)

mp

−32 °C (lit.)

mp

−32 °C (lit.)

mp

−32 °C (lit.)

mp

-31.8 °C

form

liquid

form

liquid

form

-

form

liquid

refractive index

n20/D 1.386 (lit.)

refractive index

n20/D 1.386 (lit.)

refractive index

n20/D 1.386 (lit.), n20/D 1.387

refractive index

-

一般描述

5-氟-2′-脱氧脲核苷，也称为氟脲苷，可在癌细胞中引起DNA介导的细胞毒性作用。[1]氟脲苷可有效治疗肝癌[2] 并且能够清除金黄色葡萄球菌（ Staphylococcus aureus）的毒性。[3]氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。[4]氟脲苷能够有效治疗实体瘤和晚期癌症。[5]

应用

5-氟-2′-脱氧脲核苷已被用作施旺（schwann）细胞增殖[6]、胶质细胞增殖[7][8] 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。[9]

生化/生理作用

一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P330 + P331 + P310

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCM6224
    BCCH8275
    BCCJ4890
    BCCC6160
    SLCB5571

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