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Merck
CN

F0503

Sigma-Aldrich

5-氟-2′-脱氧尿嘧啶核苷

thymidylate synthase inhibitor

别名:

2′-脱氧-5-氟脲苷, FUDR, 氟脲苷

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About This Item

经验公式(希尔记法):
C9H11FN2O5
CAS号:
分子量:
246.19
Beilstein:
90221
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

检测方案

≥99% (HPLC)

形式

powder

mp

148 °C (lit.)

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

储存温度

room temp

SMILES字符串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI key

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

基因信息

human ... TYMS(7298)
mouse ... Tyms(22171)

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一般描述

5-氟-2′-脱氧脲核苷,也称为氟脲苷,可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌( Staphylococcus aureus)的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。

应用

5-氟-2′-脱氧脲核苷已被用作施旺(schwann)细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。

生化/生理作用

一种抗肿瘤药物,是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染,可使癌细胞培养物产生FUdR耐受性。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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