生物来源
synthetic (organic)
质量水平
检测方案
≥99% (HPLC)
形式
powder
mp
148 °C (lit.)
溶解性
water: 50 mg/mL, clear, colorless to faintly yellow
储存温度
room temp
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
基因信息
human ... TYMS(7298)
mouse ... Tyms(22171)
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一般描述
5-氟-2′-脱氧脲核苷,也称为氟脲苷,可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌( Staphylococcus aureus)的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。
应用
5-氟-2′-脱氧脲核苷已被用作施旺(schwann)细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。
生化/生理作用
一种抗肿瘤药物,是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染,可使癌细胞培养物产生FUdR耐受性。
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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