所有图片(1)
别名:
2-[[2-甲基-3-（三氟甲基）苯基]氨基] -3-吡啶羧酸葡甲胺盐, 氟尼辛甲葡胺
经验公式（希尔记法）:
C14H11F3N2O2·C7H17NO5
CAS号:
分子量:
491.46
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
mp
136.6-137.4 °C
溶解性
H2O: freely soluble
储存温度
room temp
SMILES字符串
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
InChI
1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
InChI key
MGCCHNLNRBULBU-WZTVWXICSA-N
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应用
氟尼辛葡甲胺已被用作电喷雾电离质谱（LC-ESI/MS）检测中的非固醇类消炎药物标准品。
氟尼辛葡甲胺（IC50 = 1 nM）可用作动物药物，用于治疗马的肠缺血、绞痛和内毒素血症。
生化/生理作用
氟尼辛葡甲胺是一种非固醇类消炎药，可阻止前列腺素合成。
COX1、COX2 和 PLA2 抑制剂非麻醉性镇痛、解热、抗炎。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Equine veterinary journal. Supplement, (39)(39), 112-116 (2011-08-04)
The effects of prostaglandins and nonsteroidal anti-inflammatory drugs (NSAIDs) on repair of equine intestinal mucosa are important since most horses with gastrointestinal diseases are routinely treated with NSAIDs, such as flunixin meglumine (FM), and these drugs can be toxic to
A Review on Flunixin Meglumine
Faiza H, et al.
International journal of medicine and medical research, 1(2), 136-138 (2016)
J Cuervo-Arango et al.
Theriogenology, 77(3), 514-524 (2011-10-01)
The development of hemorrhagic anovulatory follicles (HAF) involves luteinization and hemorrhage of the follicle. This is observed on ultrasound as an increase in the echogenicity of the granulosa layer and formation of echoic particles in the antrum. The inhibition of
Mitchel R Stacy et al.
The Journal of thoracic and cardiovascular surgery, 148(5), 2227-2233 (2014-06-24)
The clinical translation of tissue-engineered vascular grafts has been demonstrated in children. The remodeling of biodegradable, cell-seeded scaffolds to functional neovessels has been partially attributed to matrix metalloproteinases. Noninvasive assessment of matrix metalloproteinase activity can indicate graft remodeling and elucidate
G Pugliesi et al.
Theriogenology, 78(2), 443-454 (2012-05-15)
The beginning of postluteolysis (progesterone, <1 ng mL(-1)) in heifers was targeted by using 8 h after ultrasonic detection of a 25% decrease in CL area (cm2) and was designated Hour 0. Flunixin meglumine (FM; n=10) to inhibit PGF2α secretion
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