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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
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主要文件

安全信息

EMU090851

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Pim1

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10 G
¥509.32
100 G
¥2,060.75

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10 G
¥509.32
100 G
¥2,060.75

About This Item

UNSPSC代码:
41105324
NACRES:
NA.51

¥509.32

请联系客服了解存货情况

描述

Powered by Eupheria Biotech

产品线

MISSION®

表单

lyophilized powder

esiRNA cDNA靶序列

CGACATCAAGGACGAGAACATCTTAATCGACCTGAGCCGCGGCGAAATCAAACTCATCGACTTCGGGTCGGGGGCGCTGCTCAAGGACACAGTCTACACGGACTTTGATGGGACCCGAGTGTACAGTCCTCCAGAGTGGATTCGCTACCATCGCTACCACGGCAGGTCGGCAGCTGTCTGGTCCCTTGGGATCCTGCTCTATGACATGGTCTGCGGAGATATTCCGTTTGAGCACGATGAAGAGATCATCAAGGGCCAAGTGTTCTTCAGGCAAACTGTCTCTTCAGAGTGTCAGCACCTTATTAAATGGTGCCTGTCCCTGAGACCATCAGATCGGCCCTCCTTTGAAGAAATCCGGAACCATCCATGGATGCAGGGTGACCTCCTGCCCCAGGCAGCTTCTGAGATCCATCTGCACAGTCTGTCACCGGGGTCCAGCAAGTAGCAGCCTTTCTGCTGCTGTCTGTCAGACCCTCCAGGGAGGGAGAGCTTGTCTTCTGGCCTCCCAACAGGACCCTGCGTGACGATGCAGGGACAGCAATGACAACTCATTCCAGACTCCAGGTCC

基因组数据库 |小鼠登记号

ENSMUSG00000024014

NCBI登记号

NM_008842

运输

ambient

储存温度

−20°C

基因信息

mouse ... PIM1(18712) , Pim1(18712)

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此商品
473124751347911
Fmoc-Thr(tBu)-OH ≥98.0% (HPLC)

47622

Fmoc-Thr(tBu)-OH

Fmoc-D-Thr(tBu)-OH ≥98.0% (TLC)

47312

Fmoc-D-Thr(tBu)-OH

Fmoc-Thr(Bzl)-OH ≥98.0% (TLC)

47513

Fmoc-Thr(Bzl)-OH

Fmoc-β-Homothr(tBu)-OH ≥96.0% (HPLC)

47911

Fmoc-β-Homothr(tBu)-OH

assay

≥98.0% (HPLC)

assay

≥98.0% (TLC)

assay

≥98.0% (TLC)

assay

≥96.0% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

optical activity

[α]20/D +16±1°, c = 1% in ethyl acetate

optical activity

[α]20/D −15±1.5°, c = 1% in ethyl acetate

optical activity

-

optical activity

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

reaction suitability

reaction type: C-H Activation

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

一般描述

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法律信息

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    Shabana Din et al.
    Circulation research, 115(3), 376-387 (2014-06-12)
    The senescent cardiac phenotype is accompanied by changes in mitochondrial function and biogenesis causing impairment in energy provision. The relationship between myocardial senescence and Pim kinases deserves attention because Pim-1 kinase is cardioprotective, in part, by preservation of mitochondrial integrity.
    Meng Zhang et al.
    Cancer science, 109(5), 1468-1479 (2018-03-09)
    Cancer cells metabolize glucose mainly by glycolysis and are well adapted to metabolic stress. Pim1 is an oncogene that promotes colorectal cancer (CRC) growth and metastasis, and its expression is positively correlated with CRC progression. However, the mechanism underlying Pim1

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