描述
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质量水平
产品线
MISSION®
形式
lyophilized powder
esiRNA cDNA靶序列
CAAGGCTCAGAACATCAGCAAGCTGGTTCTGTACACAGACAGCATGTTCACCATCAATGGGATAACTAACTGGGTTCAGGGCTGGAAGAAGAATGGCTGGAGAACAAGTACAGGGAAAGATGTGATCAACAAGGAGGACTTCATGGAGCTGGACGAGCTCACTCAGGGCATGGACATCCAGTGGATGCACATTCCTGGTCACTCAGGATTTGTGGGCAATGAAGAGGCCGACAGACTGGCACGGGAAGGAGCGAAGCAGTCTGAGGACTGAGCAGAGGAGCTGCTGCCGACTCAGACCCAAGGCAGAGGCTGTTTCTTTACCCTGCCGTGCACTGAGCTGTGCATGGAGGACACAGTGTAACCTGTGGCACAGCTTGGTGAGACGTGCTTACATAATGGAAAGGAAGTGTTAAATCCTGCTTTTGTGAGATTTCAGGGTCTGTCCCAA
基因组数据库 |小鼠登记号
NCBI登记号
运输
ambient
储存温度
−20°C
基因信息
mouse ... RNASEH1(19819) , Rnaseh1(19819)
相关类别
一般描述
MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
法律信息
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Shin-Ichiro Hori et al.
Biochemical and biophysical research communications, 464(2), 506-511 (2015-07-15)
Antisense oligonucleotides (ASOs) can suppress the expression of a target gene by cleaving pre-mRNA and/or mature mRNA via RNase H1. Following the initial endonucleolytic cleavage by RNase H1, the target RNAs are degraded by a mechanism that is poorly understood.
Matthias Groh et al.
PLoS genetics, 10(5), e1004318-e1004318 (2014-05-03)
Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structures over repeat regions were proposed
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