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EHU098701

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA
Price: 3096.05 CNY
Availability: InStock

targeting human MAPT

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20 μG

¥3,096.05

50 μG

¥5,474.07

¥3,096.05

预计发货时间2025年7月15日详情

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20 μG

¥3,096.05

50 μG

¥5,474.07

About This Item

UNSPSC代码:

41105324

NACRES:

NA.51

¥3,096.05

预计发货时间2025年7月15日详情

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此商品	EHU115811	EHU061381	EHU007701
EHU098701 MISSION^® esiRNA	EHU115811 MISSION^® esiRNA	EHU061381 MISSION^® esiRNA	EHU007701 MISSION^® esiRNA
esiRNA cDNA target sequence AAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGACTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGAGAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCTCCTCCACCGGCAGCATCGACATGGTAGACTCGCC	esiRNA cDNA target sequence AGGAAAGGCTTCCACAAGGTCATGGAGGGCATCCACAAGGCCATCGAGCTGGGCTACAACCCTGTGAAGGTGAACTGTGTGGTGATGCGAGGCCTTAACGAGGATGAACTCCTGGACTTTGCGGCCTTGACTGAGGGCCTCCCCCTGGATGTGCGCTTCATAGAGTATATGCCCTTTGATGGCAACAAGTGGAACTTCAAGAAGATGGTCAGCTATAAGGAGATGCTAGACACTGTCCGGCAGCAGTGGCCAGAGCTGGAGAAGGTGCCAGAGGAGGAATCCAGCACAGCCAAGGCCTTTAAAATCCCTGGCTTCCAAGGCCAGATCAGCTTCATCACATCCATGTCTGAGCATTTCTGTGGGACCTGCAACCGCCTGCGAATCACAGCTGATGGGAACC	esiRNA cDNA target sequence GCCCGATTCCTTCATGCTATATCTCATGAACCTCTGTAATCTTGGGGGAGAGACTATATTTAATGATGACAAACCTGTCACCAGTGTAGCAACAACAGTGTGAGGACAAAAGCAAATAAAAATTAAGAAGCGTTCAAATTTATATTCAACAAGGAAGTCATTTCAATCAACAACTTCTGCTGCATTATTTTTCCAAGATGAACCGATACACAACCATGAGACAGTTGGGGGACGGCACGTATGGGAGTGTGCTTATGGGCAAGAGTAATGAATCCGGGGAGCTGGTGGCCATCAAAAGGATGAAGAGAAAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGAAGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAAGTTATCAGAGAAAATGACCA	esiRNA cDNA target sequence GATTCGTTTGTGTGCCAGTGCTTTGAAGGTTATATACTCCGTGAAGATGGAAAAACCTGCAGAAGGAAAGATGTCTGCCAAGCTATAGACCATGGCTGTGAACACATTTGTGTGAACAGTGATGACTCATACACGTGCGAGTGCTTGGAGGGATTCCGGCTCGCTGAGGATGGGAAACGCTGCCGAAGGAAGGATGTCTGCAAATCAACCCACCATGGCTGCGAACACATTTGTGTTAATAATGGGAATTCCTACATCTGCAAATGCTCAGAGGGATTTGTTCTAGCTGAGGACGGAAGACGGTGCAAGAAATGCACTGAAGGCCCAATTGACCTGGTCTTTGTGATCGATGGATCCAAGAGTCTTGGAGAAGAGAATTTTGAGGTCGTGAAGCAGTTTGTCACTGGAATTATAGATTCCTTGACAATTTCCCCC
product line MISSION^®	product line MISSION^®	product line MISSION^®	product line MISSION^®
Ensembl \| human accession no. ENSG00000186868	Ensembl \| human accession no. ENSG00000124615	Ensembl \| human accession no. ENSG00000111837	Ensembl \| human accession no. ENSG00000132561
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

一般描述

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法律信息

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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ZCV

QCS

JRR

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Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury.

Sheng Yi et al.

Journal of cell science, 132(6) (2019-02-21)

Tau protein (encoded by the gene microtubule-associated protein tau, Mapt) is essential for the assembly and stability of microtubule and the functional maintenance of the nervous system. Tau is highly abundant in neurons and is detectable in astrocytes and oligodendrocytes.

The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Tomi Rantamäki et al.

PloS one, 8(7), e68722-e68722 (2013-07-12)

Brain-derived neurotrophic factor (BDNF) importantly regulates learning and memory and supports the survival of injured neurons. Reduced BDNF levels have been detected in the brains of Alzheimer's disease (AD) patients but the exact role of BDNF in the pathophysiology of

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.

Varun Balaji et al.

Autophagy, 14(12), 2139-2154 (2018-08-28)

Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers

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主要文件

安全信息

MISSION^® esiRNA

targeting human MAPT

选择尺寸