产品名称
MISSION® esiRNA, targeting human SMARCAL1
description
Powered by Eupheria Biotech
product line
MISSION®
form
lyophilized powder
esiRNA cDNA target sequence
TGTTTGCTGAGCTGTTTTGGAACCCAGGGGTGCTGATCCAGGCTGAGGACCGCGTGCACCGCATTGGACAGACCAGCTCCGTGGGCATTCACTACCTCGTGGCAAAGGGCACAGCTGATGACTACCTTTGGCCCCTGATTCAAGAGAAGATTAAAGTTCTGGCAGAAGCCGGGCTTTCTGAGACCAATTTTTCAGAAATGACAGAATCCACTGATTACCTCTACAAGGACCCAAAGCAGCAGAAGATCTACGACCTATTCCAGAAGTCCTTTGAGAAAGAAGGAAGTGATATGGAGCTCCTGGAAGCAGCAGAGTCCTTTGACCCAGGAAGTGCTTCAGGAACATCTGGAAGTAGTTCCCAGAACATGGGAGACACCCTGGATGAAAGCTCATTGACAGCCAGTCCACAGAAG
Ensembl | human accession no.
NCBI accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... SMARCAL1(50485), SMARCAL1(50485)
General description
MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Annabel Quinet et al.
Molecular cell, 77(3), 461-474 (2019-11-05)
Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation is no longer detectable in BRCA1-deficient cancer cells exposed to
Angelo Taglialatela et al.
Molecular cell, 68(2), 414-430 (2017-10-21)
To ensure the completion of DNA replication and maintenance of genome integrity, DNA repair factors protect stalled replication forks upon replication stress. Previous studies have identified a critical role for the tumor suppressors BRCA1 and BRCA2 in preventing the degradation
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