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Merck
CN
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主要文件

安全信息

E9256

Sigma-Aldrich

硬脂酸红霉素

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About This Item

经验公式（希尔记法）:
C37H67NO13 · C18H36O2
CAS号:
643-22-1
分子量:
1018.40
EC 号:
211-396-1
MDL编号:
MFCD00084690
UNSPSC代码:
41116107
PubChem化学物质编号:
24894693

生物来源

synthetic

表单

solid

颜色

white to off-white

溶解性

ethanol: 50 mg/mL, clear to very slightly hazy, colorless

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCCCCCCC(O)=O.CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@H](C)C(=O)C(C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13.C18H36O2/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-17H2,1H3,(H,19,20)/t18-,19+,20?,21+,22-,23-,24-,25-,26-,28+,29+,30+,31-,32-,34-,35-,36+,37?;/m0./s1

InChI key

YAVZHCFFUATPRK-JGJPHTNUSA-N

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一般描述

Chemical structure: macrolide

应用

Erythromycin stearate is used to study leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. It is also used to study abnormal polymorphonuclear leucocyte migration and chemotaxis.

生化/生理作用

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

预防措施声明

P261 - P280 - P342 + P311

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBF3737V
SLBD5124V
108H1435
096K1801
038F0133

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Rosacea fulminans in pregnancy with ocular perforation.
Fernanda Ayres de Morais e Silva et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 9(7), 542-543 (2011-03-04)
Prevention of bacterial endocarditis.
JAMA, 265(13), 1686-1688 (1991-04-03)
G A Kunkle et al.
Journal of the American Animal Hospital Association, 31(1), 46-55 (1995-01-01)
This epidemiologic study surveyed pet owners for observations of adverse reactions to oral antibacterials which were prescribed to outpatients at a university teaching hospital. Multiple questions were asked of all clients whose dog or cat was treated during the 18-month
Erythromycin deafness and cimetidine treatment.
N Mogford et al.
BMJ (Clinical research ed.), 309(6969), 1620-1620 (1994-12-17)
P Aho et al.
The Journal of antimicrobial chemotherapy, 21 Suppl D, 29-32 (1988-06-01)
The effect of erythromycin, doxycycline and phenoxymethylpenicillin on human polymorphonuclear leucocyte (PMNL) chemotaxis was studied in vitro with Boyden's filter technique. Both erythromycin base and 2'-acetyl erythromycin stearate increased the PMNL chemotaxis significantly at concentrations greater than or equal to
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