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Merck
CN
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文件

安全信息

E9256

Sigma-Aldrich

硬脂酸红霉素

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About This Item

经验公式（希尔记法）:
C37H67NO13 · C18H36O2
CAS号:
643-22-1
分子量:
1018.40
EC 号:
211-396-1
MDL编号:
MFCD00084690
UNSPSC代码:
51101500
PubChem化学物质编号:
24894693

生物来源

synthetic

形式

solid

颜色

white to off-white

溶解性

ethanol: 50 mg/mL, clear to very slightly hazy, colorless

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCCCCCCC(O)=O.CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@H](C)C(=O)C(C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13.C18H36O2/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-17H2,1H3,(H,19,20)/t18-,19+,20?,21+,22-,23-,24-,25-,26-,28+,29+,30+,31-,32-,34-,35-,36+,37?;/m0./s1

InChI key

YAVZHCFFUATPRK-JGJPHTNUSA-N

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一般描述

Chemical structure: macrolide

应用

Erythromycin stearate is used to study leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. It is also used to study abnormal polymorphonuclear leucocyte migration and chemotaxis.

生化/生理作用

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

预防措施声明

P261 - P280 - P342 + P311

危险分类

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

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G K Sandor et al.
Journal (Canadian Dental Association), 57(4), 321-325 (1991-04-01)
Mitral valve prolapse syndrome (MVPS) is the name given to the heart valve abnormality described by Barlow over two decades ago. This condition is of particular importance to the dentist as these patients are thought to be at risk of
H Kawai et al.
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 68(11), 1324-1329 (1994-11-01)
Although erythromycin estolate has been fully assessed for pertussis treatment, the evaluation of erythromycin ethylsuccinate and stearate, the main erythromycin preparations used in Japan and the US, is inadequate. We evaluated these preparations to establish an appropriate treatment for pertussis
E Kita et al.
The Journal of antimicrobial chemotherapy, 27(3), 273-284 (1991-03-01)
The effects of erythromycin stearate over a concentration range of 0.1-10 mg/l on production of elastase, protease and leucocidin by clinical isolates of Pseudomonas aeruginosa were investigated. Growth of P. aeruginosa N42 in broth was not affected significantly during 24
M V Martin et al.
British dental journal, 183(4), 135-137 (1997-08-23)
To evaluate shortened courses of antibiotics in the management of dentoalveolar abscesses. Prospective clinical study over a 3-year period. Examinations department of the Liverpool University Dental Hospital. 759 patients, with acute dentoalveolar abscesses associated with swelling, and an elevation of
A S Amin et al.
Journal of pharmaceutical and biomedical analysis, 14(11), 1625-1629 (1996-08-01)
A simple and selective method for the determination of erythromycin and its stearate and succinate esters in their pure forms and in pharmaceutical formulations is described. The procedure is based on the formation of a blue-coloured (lambda max = 633
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