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Merck
CN

E9256

硬脂酸红霉素

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关于此项目

经验公式（希尔记法）:
C37H67NO13 · C18H36O2
化学文摘社编号:
643-22-1
分子量:
1018.40
UNSPSC Code:
41116107
PubChem Substance ID:
24894693
EC Number:
211-396-1
MDL number:
MFCD00084690

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color

white to off-white

InChI key

YAVZHCFFUATPRK-JGJPHTNUSA-N

InChI

1S/C37H67NO13.C18H36O2/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-17H2,1H3,(H,19,20)/t18-,19+,20?,21+,22-,23-,24-,25-,26-,28+,29+,30+,31-,32-,34-,35-,36+,37?;/m0./s1

SMILES string

CCCCCCCCCCCCCCCCCC(O)=O.CC[C@@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@H](C)C(=O)C(C)[C@@H](O)[C@]1(C)O

biological source

synthetic

form

solid

solubility

ethanol: 50 mg/mL, clear to very slightly hazy, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

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General description

Chemical structure: macrolide

Application

Erythromycin stearate is used to study leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. It is also used to study abnormal polymorphonuclear leucocyte migration and chemotaxis.

Biochem/physiol Actions

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

13 - Non Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBF3737V
SLBD5124V
108H1435
096K1801
038F0133

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E Kita et al.
The Journal of antimicrobial chemotherapy, 27(3), 273-284 (1991-03-01)
The effects of erythromycin stearate over a concentration range of 0.1-10 mg/l on production of elastase, protease and leucocidin by clinical isolates of Pseudomonas aeruginosa were investigated. Growth of P. aeruginosa N42 in broth was not affected significantly during 24
A S Amin et al.
Journal of pharmaceutical and biomedical analysis, 14(11), 1625-1629 (1996-08-01)
A simple and selective method for the determination of erythromycin and its stearate and succinate esters in their pure forms and in pharmaceutical formulations is described. The procedure is based on the formation of a blue-coloured (lambda max = 633
O Paulsen et al.
Scandinavian journal of infectious diseases, 24(2), 219-225 (1992-01-01)
The efficacy and tolerance of roxithromycin 150 mg b.i.d. were compared with those of erythromycin stearate 500 mg b.i.d. in patients with lower respiratory tract infections. Out of 86 patients recruited for the study, 79 were evaluable for tolerance and
M V Martin et al.
British dental journal, 183(4), 135-137 (1997-08-23)
To evaluate shortened courses of antibiotics in the management of dentoalveolar abscesses. Prospective clinical study over a 3-year period. Examinations department of the Liverpool University Dental Hospital. 759 patients, with acute dentoalveolar abscesses associated with swelling, and an elevation of
H Kawai et al.
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 68(11), 1324-1329 (1994-11-01)
Although erythromycin estolate has been fully assessed for pertussis treatment, the evaluation of erythromycin ethylsuccinate and stearate, the main erythromycin preparations used in Japan and the US, is inadequate. We evaluated these preparations to establish an appropriate treatment for pertussis
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