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文件

安全信息

E9012

Sigma-Aldrich

Endothelin 2 human

≥97% (HPLC), powder

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别名:
ET-2
经验公式（希尔记法）:
C115H160N26O32S4
CAS号:
123562-20-9
分子量:
2546.92
MDL编号:
MFCD00133306
UNSPSC代码:
12352200
PubChem化学物质编号:
24894687
NACRES:
NA.77

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

颜色

white

UniProt登记号

P20800

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]2CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC3=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc6ccc(O)cc6)C(=O)N[C@@H](Cc7ccccc7)C(=O)N2)[C@@H](C)CC)C(=O)N[C@@H](Cc8c[nH]c9ccccc89)C(O)=O

InChI

1S/C115H160N26O32S4/c1-11-59(9)93(113(170)132-82(115(172)173)41-64-46-120-71-27-19-17-25-68(64)71)141-114(171)94(60(10)12-2)140-105(162)81(44-91(150)151)130-99(156)75(37-57(5)6)125-103(160)79(42-65-47-118-55-121-65)128-109(166)86-52-175-174-51-69(117)95(152)133-83(48-142)108(165)138-87-53-176-177-54-88(111(168)139-92(58(7)8)112(169)131-77(39-62-29-31-66(145)32-30-62)100(157)126-76(101(158)137-86)38-61-22-14-13-15-23-61)136-97(154)73(33-34-89(146)147)123-96(153)72(28-20-21-35-116)122-104(161)80(43-90(148)149)129-98(155)74(36-56(3)4)124-102(159)78(40-63-45-119-70-26-18-16-24-67(63)70)127-106(163)84(49-143)134-107(164)85(50-144)135-110(87)167/h13-19,22-27,29-32,45-47,55-60,69,72-88,92-94,119-120,142-145H,11-12,20-21,28,33-44,48-54,116-117H2,1-10H3,(H,118,121)(H,122,161)(H,123,153)(H,124,159)(H,125,160)(H,126,157)(H,127,163)(H,128,166)(H,129,155)(H,130,156)(H,131,169)(H,132,170)(H,133,152)(H,134,164)(H,135,167)(H,136,154)(H,137,158)(H,138,165)(H,139,168)(H,140,162)(H,141,171)(H,146,147)(H,148,149)(H,150,151)(H,172,173)/t59-,60-,69-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,92-,93-,94-/m0/s1

InChI key

MLFJHYIHIKEBTQ-IYRKOGFYSA-N

基因信息

human ... EDN2(1907)

相关类别

一般描述

Endothelin-2 (ET-2) is a member of the endothelin family, which also includes ET-1 and ET-3. ET-2 is the human ortholog of mouse and rat vasoactive intestinal contractor (VIC). These peptides are characterized by two disulfide linkages. ET-2 is predominantly expressed in cerebrum, stomach, intestine, ovary, uterus and testis.

生化/生理作用

Endothelin-2 (ET-2) has a regulatory role in multiple cancer types, such as breast and clear cell renal cell carcinoma (ccRCC). It is overexpressed during early stages of non-metastasized ccRCC, and is thought have a role in the progression of the same. It is a hypoxia-related factor, and might have protective action against cell death in neuronal diseases. It acts as a ligand for ET-A and ET-B receptors, which results in vasoconstriction. A985 polymorphism in this gene is thought play a protective role in cardiovascular diseases, but it acts as a susceptibility factor in atrial fibrillation in hypertrophic cardiomyopathy patients. In neural retina, it suppresses angiogenesis, and facilitates the tip cell state in endothelial cells.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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Amir Rattner et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(40), E3830-E3839 (2013-09-18)
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here, we report that constitutive overexpression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell migration across the retinal surface and
Premkumari Kumarathasan et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 21(3), 257-266 (2016-02-24)
There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was
Brian M Bot et al.
Human pathology, 43(6), 843-849 (2011-11-04)
Despite the rising incidence of clear cell renal cell carcinoma, the molecular events that support its development and progression remain unclear. Herein, we evaluate the association of endothelin 2 expression with both clear cell renal cell carcinoma development and progression-free
G L Lambert et al.
Journal of molecular endocrinology, 24(2), 273-283 (2000-04-06)
ABSTRACT The synthesis of the vasoconstrictor peptide endothelin-2 (ET-2) is dependent on hydrolysis of the biologically inactive intermediate big ET-2 by an endothelin-converting enzyme (ECE). Here, mechanisms inducing ET-2 synthesis have been investigated using the human renal adenocarcinoma cell line
Prem Kumarathasan et al.
PloS one, 8(6), e65486-e65486 (2013-07-11)
There is evidence for a role of ionizing radiation in cardiovascular diseases. The goal of this work was to identify changes in oxidative and nitrative stress pathways and the status of the endothelinergic system during progression of atherosclerosis in ApoE-deficient
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