质量水平
检测方案
≥98% (HPLC)
形式
solid
溶解性
DMSO: soluble 19 mg/mL
SMILES字符串
COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
InChI
1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
应用
Exo 1 已被用作 BRB80 缓冲液的组成成分,以被用于研究外壳蛋白 1 (COPI) 介导的膜运输。它也被用作高尔基体抑制剂来研究其对长散布的核元件 1 (L1) 逆转录转座的影响。
生化/生理作用
Exo 1 是一种可渗透细胞的邻氨基苯甲酸甲酯类似物,可促进二磷酸腺苷 (ADP)-核糖基化因子 (ARF) 1 从高尔基体膜释放。它还可抑制内质网 (ER) 和高尔基体之间的膜运输。
可逆的胞吐抑制剂; 高尔基体ARF 1(ADP-核糖基化因子)GTPase激活剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Marine biology, 164(2), 30-30 (2017-01-31)
Many marine megavertebrate taxa, including sea turtles, disperse widely from their hatching or birthing locations but display natal homing as adults. We used flipper tagging, satellite tracking and genetics to identify the origin of loggerhead turtles living in Amvrakikos Gulf
Scientific reports, 10(1), 12398-12398 (2020-07-28)
CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life
Proceedings of the National Academy of Sciences of the United States of America, 100(11), 6469-6474 (2003-05-10)
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus
Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)
Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of
Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila
Bio-protocol, 7, e2225-e2225 (2017)
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