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Merck
CN

E8004

β-Estradiol 17-cypionate

别名:

1,3,5(10)-Estratriene-3,17β-diol 17-cyclopentylpropionate, 3,17β-Hydroxy-1,3,5(10)-estratriene 17-cyclopentylpropionate, Depoestradiol

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关于此项目

经验公式（希尔记法）:
C26H36O3
化学文摘社编号:
313-06-4
分子量:
396.56
NACRES:
NA.77
PubChem Substance ID:
24894663
UNSPSC Code:
12352200
EC Number:
206-237-8
MDL number:
MFCD00056558
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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InChI key

UOACKFBJUYNSLK-XRKIENNPSA-N

InChI

1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1

SMILES string

[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24)OC(=O)CCC5CCCC5

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... ESR1(2099)

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKDB0542
MKCW1862
MKCR8411
MKCM8064
MKCL3909

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Morgan D Ashworth et al.
Reproductive toxicology (Elmsford, N.Y.), 34(1), 8-15 (2012-04-14)
Estrogen prepares the uterus for implantation and is highly conserved in mammals. However, administration of estrogen to pigs earlier than normal conceptus secretion is characterized by complete embryonic mortality by days 15-18. The objective of this study was to characterize
Morgan D Ashworth et al.
Animal reproduction science, 122(3-4), 215-221 (2010-09-21)
In pigs, administration of estrogen to gilts on Days 9 and 10 of pregnancy causes conceptus fragmentation and death between Days 15 and 18 of gestation. Conceptus degeneration is associated with breakdown of the microvilli surface glycocalyx on the lumenal
Bernard G Steinetz et al.
American journal of veterinary research, 69(1), 59-67 (2008-01-03)
To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones. 7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-)
G A Perry et al.
Journal of animal science, 86(11), 2928-2935 (2008-07-22)
Cows that exhibit estrus within 24 h of fixed-time AI have elevated concentrations of estradiol and greater pregnancy rates compared with cows not in estrus. Our objective was to determine whether estradiol, estrus, or both had an effect on uterine
José Alfredo Sierra-Ramírez et al.
Contraception, 84(6), 565-570 (2011-11-15)
The efficacy of contraceptives is affected by its route and ease of administration. Herein, both pharmacokinetics and pharmacodynamics of the once-a-month combined injectable contraceptive medroxyprogesterone acetate (MPA) plus estradiol cypionate (E(2)-Cyp) were compared after intramuscular (IM) or subcutaneous (SC) injection
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