E7906
艾美拉唑镁抗溃疡病药 镁盐 水合物
≥98% (HPLC), proton pump inhibitor, powder
别名:
(S)-奥美拉唑镁, (T-4)-双[6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基-κO]-1H-苯并咪唑基-κN3]-镁 水合物, 埃索美拉唑镁三水合物
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关于此项目
经验公式（希尔记法）:
C34H36MgN6O6S2 · xH2O
化学文摘社编号:
分子量:
713.12 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
艾美拉唑镁抗溃疡病药 镁盐 水合物, ≥98% (HPLC)
SMILES string
O.COc1ccc2n([Mg]n3c(nc4cc(OC)ccc34)S(=O)Cc5ncc(C)c(OC)c5C)c(nc2c1)S(=O)Cc6ncc(C)c(OC)c6C
InChI
1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;/t2*24-;;/m00../s1
InChI key
LGRFYKXKCZKDLS-DIYDTZFBSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -128 to -146°, c = 0.5 in methanol
color
white to off-white
solubility
DMSO: ≥5 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
Quality Level
相关类别
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Esomeprazole
Scott LJ, et al.
Drugs, 62(10), 1503-1538 (2002)
Yukiko Nakagawa et al.
Biological & pharmaceutical bulletin, 43(4), 682-687 (2020-04-03)
We previously showed that adhesive aggregates were formed when levofloxacin hydrate tablets and lansoprazole orally disintegrating (OD) tablets were suspended in water in the clinical context. In this study, we have clarified the factors causing aggregate formation, focusing on the
Mark Rochman et al.
The Journal of allergy and clinical immunology, 147(5), 1924-1935 (2020-12-09)
Proton pump inhibitors (PPIs) have been recognized as a primary treatment of eosinophilic esophagitis (EoE), an allergic inflammatory disease of the esophageal mucosa. The mechanisms underlying esophageal epithelial responses to PPIs remain poorly understood. We hypothesized that PPIs can counteract
Esomeprazole increases airway surface liquid pH in primary Cystic Fibrosis epithelial cells
Delpiano L, et al.
Frontiers in Pharmacology, 9 (2018)
A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD)
Kalaitzakis E and Bjornsson E
Therapeutics and Clinical Risk Management, 3(4), 653-653 (2007)
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