生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~35 kDa
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ENDOG(2021)
mouse ... Endog(13804)
rat ... Endog(362100)
免疫原
synthetic peptide corresponding to amino acids 55-70 of human EndoG.
应用
Anti-Endonuclease G antibody produced in rabbit is suitable for western blotting at a dilution of 2μg/mL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
Endonuclease G, mitochondrial is an enzyme encoded by the ENDOG gene in humans. It is mapped to human chromosomes 9q34.1. EndoG a member of DNA/RNA nonspecific ββα-Me-finger nucleases that is involved in apoptosis and normal cellular proliferation. EndoG is localized in the mitochondria of young cells, but relocalizes to the nucleus upon senescence. It plays an important role in the senescence program of human endothelial cells. ENDOG is alo involved in mitochondrial-mediated apoptotic signaling in older human muscle.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Shih-Lu Wu et al.
Journal of biomedical science, 16, 6-6 (2009-03-11)
Endonuclease G (EndoG), a member of DNA/RNA nonspecific betabetaalpha-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG and proposed the catalytic mechanism of EndoG. To identify the
Gilles Gouspillou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1621-1633 (2013-12-29)
Mitochondrial dysfunction is implicated in skeletal muscle atrophy and dysfunction with aging, with strong support for an increased mitochondrial-mediated apoptosis in sedentary rodent models. Whether this applies to aged human muscle is unknown, nor is it clear whether these changes
Thomas Diener et al.
Experimental gerontology, 45(7-8), 638-644 (2010-03-10)
Mitotic cells in culture show a limited replicative potential and after extended subculturing undergo a terminal growth arrest termed cellular senescence. When cells reach the senescent phenotype, this is accompanied by a significant change in the cellular phenotype and massive
Núria Bahi et al.
The Journal of biological chemistry, 281(32), 22943-22952 (2006-06-07)
Differentiated cardiomyocytes are resistant to caspase-dependent cell death; however, the mechanisms involved are still uncertain. We previously reported that low Apaf1 expression partially accounts for cardiomyocyte resistance to apoptosis. Here, we extend the knowledge on the molecular basis of cardiac
Takumi Kudo et al.
Cancer research, 72(11), 2901-2911 (2012-05-18)
RASSF3 is the smallest member of the RASSF family of proteins that function as tumor suppressors. Unlike other members of this important family, the mechanisms through which RASSF3 suppresses tumor formation remain unknown. Here, we show that RASSF3 expression induces
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门