E5264
2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷高氯酸酯
analytical standard, for drug analysis
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H23N · HClO4
化学文摘社编号:
分子量:
377.86
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
InChI
1S/C20H23N.ClHO4/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;2-1(3,4)5/h4-14,16H,15H2,1-3H3;(H,2,3,4,5)/b19-4-;
SMILES string
OCl(=O)(=O)=O.C\C=C1/N(C)C(C)CC1(c2ccccc2)c3ccccc3
InChI key
CBNJWAYHGKHAFJ-YOJQKEKBSA-N
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
veterinary
format
neat
storage temp.
2-8°C
Quality Level
General description
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate is a primary metabolite of methadone.
Application
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate has been used as a standard in the quantitative determination of of methadone and metabolites in human meconium using liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry technique (LC–APCI–MS/MS).
A metabolite of methadone, useful as a marker in GC-MS analyses.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Determination of methadone, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine, 2-ethyl-5-methyl-3, 3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry
Choo.ER, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 814, 369-373 (2005)
G I Kang et al.
Journal of chromatography, 231(2), 311-319 (1982-09-10)
The analysis of methadone and its metabolites in biological fluids by gas chromatography--mass spectrometry is described with deuterated methadone and metabolites as internal standards. The method allowed the determination of 20 ng methadone in 0.5 ml of plasma or saliva.
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
Ricarda Jantos et al.
Forensic science international, 226(1-3), 254-260 (2013-02-21)
Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories
Karen Marie Dollerup Holm et al.
Journal of analytical toxicology, 36(7), 487-496 (2012-07-11)
We developed a method based on liquid chromatography coupled with tandem mass spectrometry to quantify individual enantiomers of methadone and its primary metabolite, R/S-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), in postmortem blood and brain tissue. Samples were prepared with a Tecan Evo robotic system.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持