Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse

human EDG-5/S1P₂ unique C-terminal peptide.

Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung.

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

EDG-5/S1P₂ belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P₂ is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue.

Purified from in vitro cell culture supernatants using protein A.

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