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产品名称
肝素结合EGF 样生长因子 人, HB-EGF, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in baculovirus infected Sf21 cells
方案
≥97% (SDS-PAGE and N-terminal analysis)
表单
lyophilized powder
效能
≤3 ng/mL
质量
endotoxin tested
分子量
9.5 kDa
包装
pkg of 50 and 250 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... HBEGF(1839) , HBEGF(1839)
生化/生理作用
与BTC一样，肝素结合表皮生长因子（HB-EGF）是肝素结合EGF家族的成员。天然可溶性HB-EGF是一种19 kDa的糖蛋白，因异质性截短而具有多种形式。可溶性HB-EGF对成纤维细胞、角质形成细胞和平滑肌细胞具有促有丝分裂和趋化作用，但对毛细血管内皮细胞则没有。在单核细胞、巨噬细胞以及血管和主动脉平滑肌细胞（SMC）中可检测到HB-EGF的产生。HB-EGF在动脉粥样硬化的发病机理中可能会起作用。它也可能是Jun诱导的致癌转化的效应因子。HB-EGF可以高亲和力与EGFR结合，并以中等亲和力与ErbB结合。
外形
从含有2.5 mg牛血清白蛋白并经0.2 μm滤膜过滤的磷酸盐缓冲盐中冻干。
分析说明
生物活性通过它在EGF反应性BALB/3T3细胞中刺激3H-胸苷掺入的能力来测量。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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