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Merck
CN
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文件

安全信息

E3888

Sigma-Aldrich

[D-Pen2,5]-Enkephalin hydrate

≥95% (HPLC)

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别名:
DPDPE
经验公式（希尔记法）:
C30H39N5O7S2 · xH2O
分子量:
645.79 (anhydrous basis)
MDL编号:
MFCD00076430
UNSPSC代码:
12352209
PubChem化学物质编号:
329799055
NACRES:
NA.32

质量水平

200

检测方案

≥95% (HPLC)

储存温度

−20°C

SMILES字符串

CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O

InChI

1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1

InChI key

MCMMCRYPQBNCPH-WMIMKTLMSA-N

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Amino Acid Sequence

Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]

一般描述

[D-Pen2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.

应用

[D-Pen2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).

生化/生理作用

Antinociceptive activity mediated through the δ1 receptor while the modulatory activity is mediated through the δ2 receptor. Tritiated [D-Pen2,5]-enkephalin is used as a δ1 ligand.

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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D C Jewett et al.
Psychopharmacology, 127(3), 225-230 (1996-10-01)
The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisition of discriminative
S Allouche et al.
Biochemical pharmacology, 59(8), 915-925 (2000-02-29)
The two pharmacological delta-opioid receptor subtypes, delta1 and delta2, have been defined on the basis of pharmacological tools but remain to be characterized at the molecular level, since only a single cDNA has been cloned. The present study aimed to
B Gao et al.
The Journal of pharmacology and experimental therapeutics, 294(1), 73-79 (2000-06-28)
Organic anion-transporting polypeptides (Oatps) are a rapidly growing gene family of polyspecific membrane transporters. In rat brain, Oatp1 (gene symbol Slc21a1) and Oatp2 (Slc21a5) are localized at the apical and basolateral domains, respectively, of the choroid plexus epithelium. Furthermore, Oatp2
K A Witt et al.
The Journal of pharmacology and experimental therapeutics, 298(2), 848-856 (2001-07-17)
Poly(ethylene glycol), or PEG, conjugation to proteins and peptides is a growing technology used to enhance efficacy of therapeutics. This investigation assesses pharmacodynamic and pharmacokinetic characteristics of PEG-conjugated [D-Pen2,D-Pen5]-enkephalin (DPDPE), a met-enkephalin analog, in rodent (in vivo, in situ) and
Minna-Liisa Ankö et al.
BMC neuroscience, 6, 21-21 (2005-04-05)
Neuropeptide FF (NPFF) plays a role in physiological pain sensation and opioid analgesia. For example, NPFF potentiates opiate-induced analgesia and the delta opioid receptor antagonist naltrindole inhibits NPFF-induced antinociception. The nature of the interactions between NPFF and opioid receptors seems
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