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Merck
CN

E3539

Sigma-Aldrich

Proteinase 3 from human leukocytes

≥95% (PAGE)

别名:

AGP7, Myeloblastin, P29B, PR-3, PR3 Ag

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About This Item

MDL编号:
UNSPSC代码:
12352204
NACRES:
NA.54

方案

≥95% (PAGE)

表单

buffered aqueous solution

UniProt登记号

储存温度

−20°C

基因信息

human ... PRTN3(5657)

一般描述

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4

应用

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2

生化/生理作用

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
Used for the detection of anti-PR3 auto-antibodies in immunoassays.

外形

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

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