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一般描述
Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4
应用
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2
生化/生理作用
Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
Used for the detection of anti-PR3 auto-antibodies in immunoassays.
外形
Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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