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E3132

Sigma-Aldrich

E-64

protease inhibitor

别名:

反-环氧丁二酰基-L-亮氨酰胺基(4-胍基)丁烷, L-反-3-羧基环氧乙烷-2-羰基)-L-亮氨酰胍基丁胺, N-(反式-环氧丁二酰基)-L-亮氨酸-胍基丁基酰胺

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1 MG
¥927.90
5 MG
¥3,193.50
10 MG
¥4,546.33
25 MG
¥12,080.20
50 MG
¥15,643.23

¥927.90

国内现货，预计发货时间2025年4月14日详情

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1 MG
¥927.90
5 MG
¥3,193.50
10 MG
¥4,546.33
25 MG
¥12,080.20
50 MG
¥15,643.23

About This Item

经验公式（希尔记法）:
C15H27N5O5
CAS号:
66701-25-5
分子量:
357.41
Beilstein:
1405664
MDL编号:
MFCD00080261
UNSPSC代码:
12352202
PubChem化学物质编号:
24278411
NACRES:
NA.77

¥927.90

国内现货，预计发货时间2025年4月14日详情

生物来源

synthetic (organic)

方案

≥98% (HPLC)

表单

powder

溶解性

water: 20 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCNC(N)=N

InChI

1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1

InChI key

LTLYEAJONXGNFG-HBNTYKKESA-N

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此商品
E8640324890SAE0154
E-64 protease inhibitor

E3132

E-64

E-64d protease inhibitor

E8640

E-64d

E-64 Protease Inhibitor The E-64 Protease Inhibitor, also referenced under CAS 66701-25-5, controls the biological activity of E-64 Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

324890

E-64 Protease Inhibitor

E64 Ready Made solution Non-freezing solution, 1 mg/mL

SAE0154

E64 Ready Made solution

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

biological source

-

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

solid

form

ready-to-use solution

solubility

water: 20 mg/mL, clear, colorless to faintly yellow

solubility

methanol: water (1:1): 5 mg/mL, clear, colorless

solubility

water: 20 mg/mL, DMSO: 25 mg/mL

solubility

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

一般描述

E-64 是从霉菌 日本曲霉 TPR-64中分离出来的半胱氨酸蛋白酶抑制剂。 E-64 又称N-[N-(L-3-反式-羧氧吡喃-2-羰基）-L-亮氨酰]-胍丁胺。E-64可以有效抑制各种半胱氨酸蛋白酶，特别是：
  • 组织蛋白酶K
  • 组织蛋白酶L
  • 组织蛋白酶S
E-64还可以对抗其他酶，例如：
  • 钙蛋白酶
  • 组织蛋白酶B
  • 组织蛋白酶H
  • 木瓜蛋白酶

应用

E-64是亲和纯化半胱氨酸蛋白酶的有效配体。当与硫醇化亲和基质偶联时，结合将成为可逆的，但保留了特异性。

生化/生理作用

E-64是一种不可逆的、强效的、高选择性半胱氨酸蛋白酶抑制剂。E-64不与非蛋白酶的功能性硫醇基团反应，如 L-乳酸脱氢酶或肌酸激酶。与亮抑酶肽和抗蛋白酶肽等其他半胱氨酸蛋白酶抑制剂不同，E-64不会抑制丝氨酸蛋白酶（胰蛋白酶除外）。E-64的反式环氧琥珀酰基（活性部分）不可逆地与许多半胱氨酸蛋白酶的活性巯基结合，如木瓜蛋白酶、猕猴桃酶和组织蛋白酶B、H和L，从而形成硫醚键。 E-64是一种非常有用的半胱氨酸蛋白酶抑制剂，具有特异性抑制作用，在细胞和组织中具有渗透性，毒性低，可用于 体内 研究。
有效的、不可逆的半胱氨酸蛋白酶抑制剂，如钙蛋白酶和组织蛋白酶B，该抑制剂不影响其他酶的半胱氨酸残基或者不与低分子量硫醇化合物反应。有效浓度为1-10 μM。

制备说明

E-64可溶于水。可配制成20 mg/ml的水溶液（可能需要加热）。 建议储备溶液是1 mM水溶液。用作蛋白酶抑制剂的有效浓度为1至10 μM。 水溶液储备溶液可在-20°C稳定保存数月。稀释液可在中性pH体系中稳定保存数天。 E-64在pH 2-10体系中稳定，但在氨水或HCl体系中不稳定。 E-64也溶于DMSO，可使用无水DMSO制备10 mM溶液并储存在-20℃。使用培养基进行后续稀释。将E-64溶解在0.9％氯化钠溶液中或溶解在最少量的饱和碳酸氢钠溶液中并用0.9％氯化钠稀释（用乙酸调节pH至7.0），可制备注射液。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000438433
    0000438432
    0000438432
    0000438433
    0000425639

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    F D Nascimento et al.
    Journal of dental research, 90(4), 506-511 (2011-01-21)
    Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin. This study aimed to examine the presence, source, and activity of cysteine cathepsins in human
    P M C Scaffa et al.
    Journal of dental research, 91(4), 420-425 (2012-01-24)
    The co-expression of MMPs and cysteine cathepsins in the human dentin-pulp complex indicates that both classes of enzymes can contribute to the endogenous proteolytic activity of dentin. Chlorhexidine (CHX) is an efficient inhibitor of MMP activity. This study investigated whether
    Deepak Bararia et al.
    Cell reports, 31(5), 107522-107522 (2020-04-25)
    Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 in 6% of FL (19/305). Another
    Marie-Thérèse Bawolak et al.
    Pharmacological research, 65(2), 247-253 (2011-11-24)
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    Thomas C A Blake et al.
    PLoS pathogens, 16(10), e1009007-e1009007 (2020-10-27)
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