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Merck
CN

E2271

Sigma-Aldrich

四氢嘧啶

osmoprotectant

别名:

(S)-2-甲基-1,4,5,6-四氢嘧啶-4-羧酸, 刺激物(B)

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About This Item

经验公式(希尔记法):
C6H10N2O2
CAS号:
分子量:
142.16
Beilstein:
7288977
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.25

质量水平

检测方案

≥98.0% (HPLC)
≥98.0% (TLC)

形式

powder

分子量

142.16

储存温度

room temp

SMILES字符串

CC1=N[C@@H](CCN1)C(O)=O

InChI

1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1

InChI key

WQXNXVUDBPYKBA-YFKPBYRVSA-N

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相关类别

一般描述

依克多因(Ectoine)是一种天然的环状四氢嘧啶,它是一种可以与水结合的低分子量有机渗透剂。它是一类小分子伴侣(small molecule chaperone,SMC)的一部分。

生化/生理作用

依克多因是多种微生物中的渗透保护剂,包括异养、嗜盐菌和非嗜盐菌,如链霉菌大肠杆菌。这种相容性溶质对大肠杆菌在干燥和储存过程中也有保护作用。依克多因与蛋白质和脂质双层的稳定有关。它还调节膨压的保持并减轻干燥胁迫。它可以用于治疗炎症性疾病,例如过敏性鼻炎、特应性皮炎和慢性阻塞性肺疾病。依克多因可以在体外引起DNA结构变化,并保护DNA免受电离辐射(IR)的伤害。它可以防止胰岛素淀粉样蛋白在体外形成。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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G Malin et al.
Journal of bacteriology, 178(2), 385-395 (1996-01-01)
The metabolic responses of a number of Streptomyces strains to osmotic and heat stress were studied by 13C nuclear magnetic resonance spectroscopy. During cell growth in a chemically defined medium supplemented with 0.5 M NaCl, tetrahydropyrimidine derivatives (THPs), 2-methyl-4-carboxy-5-hydroxy-3,4,5,6-tetrahydropyrimidine [THP(A)]
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer?s beta-amyloid
Kanapathipillai M, et al.
Febs Letters, 579(21), 4775-4780 (2005)
Biosynthesis of the stress-protectant and chemical chaperon ectoine: biochemistry of the transaminase EctB
Bremer E, et al.
Frontiers in Microbiology, 10, 2811-2811 (2019)
Denise Freimark et al.
Cryobiology, 63(2), 67-75 (2011-05-31)
Human mesenchymal stem cells (hMSCs) have great potential for clinical therapy and regenerative medicine. One major challenge concerning their application is the development of an efficient cryopreservation protocol since current methods result in a poor viability and high differentiation rates.
Lei Cai et al.
Microbial cell factories, 10, 88-88 (2011-11-02)
Halophilic bacteria have shown their significance in industrial production of polyhydroxyalkanoates (PHA) and are gaining more attention for genetic engineering modification. Yet, little information on the genomics and PHA related genes from halophilic bacteria have been disclosed so far. The

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