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About This Item
经验公式（希尔记法）:
C6H10N2O2
CAS号:
分子量:
142.16
Beilstein:
7288977
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.25
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一般描述
依克多因（Ectoine）是一种天然的环状四氢嘧啶，它是一种可以与水结合的低分子量有机渗透剂。它是一类小分子伴侣（small molecule chaperone，SMC）的一部分。
生化/生理作用
依克多因是多种微生物中的渗透保护剂，包括异养、嗜盐菌和非嗜盐菌，如链霉菌和大肠杆菌。这种相容性溶质对大肠杆菌在干燥和储存过程中也有保护作用。依克多因与蛋白质和脂质双层的稳定有关。它还调节膨压的保持并减轻干燥胁迫。它可以用于治疗炎症性疾病，例如过敏性鼻炎、特应性皮炎和慢性阻塞性肺疾病。依克多因可以在体外引起DNA结构变化，并保护DNA免受电离辐射（IR）的伤害。它可以防止胰岛素淀粉样蛋白在体外形成。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
G Malin et al.
Journal of bacteriology, 178(2), 385-395 (1996-01-01)
The metabolic responses of a number of Streptomyces strains to osmotic and heat stress were studied by 13C nuclear magnetic resonance spectroscopy. During cell growth in a chemically defined medium supplemented with 0.5 M NaCl, tetrahydropyrimidine derivatives (THPs), 2-methyl-4-carboxy-5-hydroxy-3,4,5,6-tetrahydropyrimidine [THP(A)]
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer?s beta-amyloid
Kanapathipillai M, et al.
Febs Letters, 579(21), 4775-4780 (2005)
Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: a randomised, comparator-controlled, intra-individual double-blind, multi-center trial
Marini A, et al.
Skin Pharmacology and Physiology, 27(2), 57-65 (2014)
Biosynthesis of the stress-protectant and chemical chaperon ectoine: biochemistry of the transaminase EctB
Bremer E, et al.
Frontiers in Microbiology, 10, 2811-2811 (2019)
Xiangyang Li et al.
Journal of bacteriology, 194(16), 4473-4474 (2012-07-31)
We present the draft genome sequence of Pseudomonas stutzeri TS44, a moderately halotolerant, arsenite-oxidizing bacterium isolated from arsenic-contaminated soil. The genome contains genes for arsenite oxidation, arsenic resistance, and ectoine/hydroxyectoine biosynthesis. The genome information will be useful for exploring adaptation
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