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Merck
CN

E2250

鞣花酸

≥95% (HPLC), powder, from tree bark

别名:

4,4′,5,5′,6,6′-六氢二苯二甲酸2,6,2′,6′-二内酯, 鞣花酸

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关于此项目

经验公式(希尔记法):
C14H6O8
化学文摘社编号:
分子量:
302.19
UNSPSC Code:
12352205
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-508-3
Beilstein/REAXYS Number:
47549
MDL number:
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产品名称

鞣花酸, ≥95% (HPLC), powder, from tree bark

InChI key

AFSDNFLWKVMVRB-UHFFFAOYSA-N

InChI

1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

SMILES string

Oc1cc2C(=O)Oc3c(O)c(O)cc4C(=O)Oc(c1O)c2-c34

biological source

tree bark

assay

≥95% (HPLC)

form

powder

shelf life

5 yr

solubility

1 M NaOH: 10 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Quality Level

Gene Information

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Biochem/physiol Actions

研究发现,鞣花酸可抑制低密度脂蛋白的氧化,因这种抗氧化活性它对人心脏具有保护作用。此外,它也具有抗癌、抗纤维化、抗疟原虫、细胞凋亡和化学预防活性。
其是一种常见的植物多酚,是谷胱甘肽S-转移酶的抑制剂。可用于血浆中XIIa因子的测定。 可在血液凝固中发生接触激活。

General description

鞣花酸是在多种水果和蔬菜中天然生成的酚酸类次级植物代谢物,通常存在于绿茶、石榴、草莓、树莓和核桃中。

Application

鞣花酸已用于:
  • 基于植物乳杆菌CECT 748T研究酚酸类膳食物质的代谢机制
  • 作为植物乳杆菌单宁酶高产的潜在底物
  • 在荨麻酚类成分和抗氧剂活性研究中作为检测标准品
  • 研究膳食鞣花酸和脂肪形成表观遗传调节之间的关系

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Diletta Balli et al.
Antioxidants (Basel, Switzerland), 9(3) (2020-03-19)
Pomegranate is receiving renewed commercial and scientific interest, therefore a deeper knowledge of the chemical composition of the fruits of less studied varieties is required. In this work, juices from arils and decoctions from mesocarp plus exocarp were prepared from
Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study.
Zonne L M Hofman et al.
The Journal of allergy and clinical immunology, 146(6), 1446-1449 (2020-05-04)
Inhae Kang et al.
The Journal of nutritional biochemistry, 25(9), 946-953 (2014-06-16)
Chromatin remodeling is a key mechanism in adipocyte differentiation. However, it is unknown whether dietary polyphenols are epigenetic effectors for adiposity control. Ellagic acid (EA) is a naturally occurring polyphenol in numerous fruits and vegetables. Recently, EA-containing foods have been
Dong Hoon Han et al.
Anticancer research, 26(5A), 3601-3606 (2006-11-11)
Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured
Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation
Meyer AS, et al.
Food Chemistry, 61(1-2), 71-75 (1998)

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