E1905
(+)-依托莫西 钠盐 水合物
≥98% (HPLC), powder, CPT-1 inhibitor
别名:
R(+)-2-[6-(4-氯苯氧基）己基]-环氧乙烷-2-羧酸 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C15H18ClO4 · Na · H2O
化学文摘社编号:
分子量:
338.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(+)-依托莫西 钠盐 水合物, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: freely soluble
storage temp.
2-8°C
SMILES string
O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI
1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
InChI key
WENJLJJSJDAJDN-QCUBGVIVSA-M
General description
(+)-依托莫西钠盐水合物属于环氧乙烷羧酸基团化合物，调节脂肪酸前体代谢通道。它有利于T细胞氧化压力并且防止T细胞分化。它能抑制脂肪酸代谢，促使饥饿和食物摄入。依托莫西削弱髓源抑制性细胞介导的肿瘤，可能具有治疗潜在价值。
Application
(+)-依托莫西钠盐水合物可用作乳腺肿瘤细胞系和小鼠肿瘤肉毒碱棕榈酰转移酶1（CTP-1）的抑制剂。它还可以用于人原发性前列腺上皮细胞和淋巴细胞的脂肪酸氧化抑制物。
Biochem/physiol Actions
不可逆O—肉毒碱棕榈酰转移酶1（CTP-1）抑制剂；PPARα 激活剂
Packaging
气密保存，隔绝光照
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells
Xu FY, et al.
Journal of Lipid Research, 44(2), 415-423 (2003)
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
OConnor RS, et al.
Scientific Reports, 8(1), 6289-6289 (2018)
Organoids model distinct Vitamin E effects at different stages of prostate cancer evolution
Njoroge RN, et al.
Scientific Reports, 7(1), 16285-16285 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E1905-25MG | 04061833602317 |
| E1905-5MG | 04061833602324 |