E1905
(+)-依托莫西 钠盐 水合物
≥98% (HPLC), powder, CPT-1 inhibitor
别名:
R(+)-2-[6-(4-氯苯氧基）己基]-环氧乙烷-2-羧酸 钠盐 水合物
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H18ClO4 · Na · H2O
化学文摘社编号:
分子量:
338.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(+)-依托莫西 钠盐 水合物, ≥98% (HPLC), powder
SMILES string
O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI key
WENJLJJSJDAJDN-QCUBGVIVSA-M
InChI
1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: freely soluble
storage temp.
2-8°C
Quality Level
Application
(+)-依托莫西钠盐水合物可用作乳腺肿瘤细胞系和小鼠肿瘤肉毒碱棕榈酰转移酶1（CTP-1）的抑制剂。它还可以用于人原发性前列腺上皮细胞和淋巴细胞的脂肪酸氧化抑制物。
Biochem/physiol Actions
不可逆O—肉毒碱棕榈酰转移酶1（CTP-1）抑制剂；PPARα 激活剂
General description
(+)-依托莫西钠盐水合物属于环氧乙烷羧酸基团化合物，调节脂肪酸前体代谢通道。它有利于T细胞氧化压力并且防止T细胞分化。它能抑制脂肪酸代谢，促使饥饿和食物摄入。依托莫西削弱髓源抑制性细胞介导的肿瘤，可能具有治疗潜在价值。
Packaging
气密保存，隔绝光照
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells
Xu FY, et al.
Journal of Lipid Research, 44(2), 415-423 (2003)
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
OConnor RS, et al.
Scientific Reports, 8(1), 6289-6289 (2018)
Milena Schönke et al.
Journal of lipid research, 59(7), 1276-1282 (2018-05-10)
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral tissues and contributes to the development of
Ibrutinib Resistance Is Reduced By Fatty Acid Oxidation Inhibition In Primary CLL Lymphocytes
Galicia-Vazquez G and Aloyz R
Frontiers in Oncology, 8, 411-411 (2018)
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
Hossain F, et al.
Cancer immunology research, 3(11), 1236-1247 (2015)
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持