生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
TFE61, monoclonal
形式
buffered aqueous solution
分子量
antigen ~35 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... E2F6(1876)
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一般描述
E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.
免疫原
recombinant human E2F6 protein
应用
Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.
生化/生理作用
The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Gwen MacDonald et al.
Breast cancer research : BCR, 9(4), R49-R49 (2007-08-01)
Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease. Transcriptional elements involved
Phillip J Iaquinta et al.
Current opinion in cell biology, 19(6), 649-657 (2007-11-23)
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs
Paloma H Giangrande et al.
Genes & development, 18(23), 2941-2951 (2004-12-03)
E2F transcription factors play a critical role in the control of cell cycle progression, regulating the expression of genes involved in DNA replication, DNA repair, mitosis, and cell fate. This involves both positive-acting and negative-acting E2F proteins, the latter group
J M Trimarchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2850-2855 (1998-04-18)
The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are
S Gaubatz et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(16), 9190-9195 (1998-08-05)
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6 lacks pocket protein binding and transactivation domains, and it is
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