E1406
恩贝酸
≥98% (HPLC), powder
别名:
2,5-二羟基-3-十一烷基-2,5-环己二烯-1,4-二酮, 恩贝灵, 恩贝酸
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关于此项目
经验公式（希尔记法）:
C17H26O4
化学文摘社编号:
分子量:
294.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-979-8
MDL number:
InChI key
IRSFLDGTOHBADP-UHFFFAOYSA-N
InChI
1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
SMILES string
CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL, H2O: insoluble
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, parasites
mode of action
DNA synthesis | interferes
Quality Level
Gene Information
human ... XIAP(331)
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General description
恩贝酸是一种天然的苯醌衍生物，最早从白花酸滕果植物中提取。它在结构上类似于泛醌。
Application
使用恩贝酸：
- 研究其对活化T细胞(NFATc1)荧光素酶活性的核因子kB配体(RANKL)诱导的核因子的受体激活剂的影响
- 研究其在介导帕金森病(PD)机制中的作用′
- 治疗全鼠胚胎，以确定其对X连锁抑制细胞凋亡蛋白(XIAP)活性的影响
Biochem/physiol Actions
恩贝酸具有抗氧化、线粒体解耦联和抗生育特性。它还具有抗糖尿病、抗惊厥、抗焦虑和抗微生物活性等作用。恩贝酸是一种有效的神经保护剂，也可作为脑卒中的辅助治疗。
恩贝酸（Embelin）是XIAP（X连锁凋亡抑制蛋白）的抑制剂；体内抗肿瘤和抗炎活性。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Swetha Pavani Rao et al.
Biochimica et biophysica acta. Bioenergetics, 1861(3), 148157-148157 (2020-01-29)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor deficits. Amongst the mechanisms proposed, mitochondrial dysfunction, reduced complex-I and PGC1α levels were found to correlate
Simone Reuter et al.
Molecular cancer research : MCR, 8(10), 1425-1436 (2010-09-10)
Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now
Rajnish Gupta et al.
Journal of diabetes, 4(3), 248-256 (2012-01-19)
The aim of the present study was to evaluate the antioxidant potential of embelin in streptozotocin-induced diabetes. Diabetes was induced in rats fasted overnight by the administration of a single dose of streptozotocin, and analyzed for blood, serum, and biological
Zhonghui Lin et al.
Chemistry & biology, 20(2), 253-261 (2013-02-27)
Plasminogen activator inhibitor-1 (PAI-1), a serpin, is the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and thus also an inhibitor of fibrinolysis and tissue remodeling. It is a potential therapeutic target in many pathological conditions, including thrombosis and cancer.
Zhen Li et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 9682495-9682495 (2019-04-25)
Embelin exhibits the broad bioactivities such as antitumor, antifertility, antidiabetic, anti-inflammatory, antioxidant, anticonvulsant, anxiolytic, antimicrobial, and hepatoprotective activity. In order to further understand the pharmacokinetic characteristics and oral bioavailability of embelin in vivo, the concentration of embelin in rat plasma
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Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
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