E1281
Anti-Ezrin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-80K, Anti-Cytovillin, Anti-p81
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, IP, WB CL
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~80 kDa
species reactivity
human, rat
technique(s)
immunohistochemistry: 20-40 μg/mL, immunoprecipitation (IP): 0.5-1 μg using RIPA extract of human A431 cells, indirect immunofluorescence: 10-20 μg/mL, western blot (chemiluminescent): 0.5-1 μg/mL using whole extract of rat NRK cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EZR(7430)
mouse ... Ezr(22350)
rat ... Ezr(54319)
正在寻找类似产品? 访问 产品对比指南
General description
Ezrin is a 80kDa membrane-associated protein that belongs to ERM (Ezrin/Radixin/Moesin) family. Ezrin is found predominantly in polarized epithelial cells such as intestinal epithelial cells, gastric parietal cells, epithelial cells of the kidney proximal tubule, terminal bronchiole of the lung, and in mesothelia.
Immunogen
synthetic peptide corresponding to amino acids 479-498 of human ezrin with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in rat and mouse differs by three amino acids.
Application
Anti-Ezrin antibody produced in rabbit has been used in:
- immunolocalization studies
- immunostaining
- immunofluorescence and immunohistochemistry
- immunoblot
Biochem/physiol Actions
Cultured neuronal cells do express ezrin to some extent, and whole brain tissue expresses low levels of ezrin. Ezrin expression is associated with malignancy in astrocytoma, osteosarcoma, mammary and pancreatic adenocarcinomas, and in cutaneous and uveal melanomas.
Ezrin promotes cell adhesion. The NH2-terminal domain negatively regulates membrane spreading and elongation properties of ezrin COOH-terminal domain. The members of ERM family are usually involved in cross-linking of plasma membrane and actin filaments. ERM proteins are involved in cell adhesion, cell shape determination, migration, and the organization of cell surface structures. They are also involved in signal transduction and apoptosis. Ezrin has been implicated in tumor progression and metastatic spread.
Physical form
Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma
Xie YH, et al.
The International Journal of Biochemistry & Cell Biology, 112(19), 79-87 (2019)
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion
Pidoux G, et al.
Journal of Cell Science, 127(19), 4172-4185 (2014)
Jorge A Lobato-Álvarez et al.
Frontiers in physiology, 7, 450-450 (2016-10-25)
Na+, K+-ATPase, or the Na+ pump, is a key component in the maintenance of the epithelial phenotype. In most epithelia, the pump is located in the basolateral domain. Studies from our laboratory have shown that the β1 subunit of Na+
Dan-Xia Deng et al.
Molecular & cellular proteomics : MCP, 22(8), 100593-100593 (2023-06-17)
Proteins containing a CAAX motif at the C-terminus undergo prenylation for localization and activity and include a series of key regulatory proteins, such as RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein, and several protein kinases and phosphatases. However
T Kondo et al.
The Journal of cell biology, 139(3), 749-758 (1997-11-14)
Breakdown of microvilli is a common early event in various types of apoptosis, but its molecular mechanism and implications remain unclear. ERM (ezrin/radixin/moesin) proteins are ubiquitously expressed microvillar proteins that are activated in the cytoplasm, translocate to the plasma membrane
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持