跳转至内容
Merck
CN

E1127

β-雌二醇17-(β-D-葡萄糖醛酸) 钠盐

≥98% (HPLC), Estradiol metabolite, powder

别名:

1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide

登录 查看组织和合同定价。

选择尺寸

关于此项目

线性分子式:
C24H31O8Na
化学文摘社编号:
15087-02-2
分子量:
470.49
UNSPSC Code:
51111800
PubChem Substance ID:
24894388
NACRES:
NA.77
MDL number:
MFCD00056557

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

β-雌二醇17-(β-D-葡萄糖醛酸) 钠盐,

SMILES string

[Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI key

GPLPNZUTAJWRLU-UHFFFAOYSA-N

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

200

相关类别

Application

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).

Biochem/physiol Actions

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000353229
0000353229
0000376255
0000376255
0000285933

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Vascular endothelial growth factor (VEGF) promotes the early development of bovine embryo in the presence of cumulus cells
Luo H, et al.
The Journal of Veterinary Medical Science, 64(11), 967-971 (2002)
Vascular endothelial growth factor has beneficial effect independent of serum components throughout oocyte maturation and early embryonic development in cattle
Luo H, et al.
Asian-Australasian Journal of Animal Sciences, 19(4), 495-499 (2006)
ATP-dependent 17-Estradiol 17-(-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP) INHIBITION BY CHOLESTATIC STEROIDS
Loe DW, et al.
The Journal of Biological Chemistry, 271, 9683-9689 (1996)
In vitro Glucuronidation of Estradiol-17 beta by Microsomes Prepared using Liver Biopsy Specimens from Dairy Cows
Kadokawa H, et al.
The Journal of Veterinary Medical Science, 69(5), 557-559 (2007)

商品

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持