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无菌性
non-sterile
方案
≥98% (HPLC)
表单
powder
溶解性
0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
运输
ambient
储存温度
−20°C
SMILES字符串
[Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
InChI
1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
InChI key
GPLPNZUTAJWRLU-UHFFFAOYSA-N
应用
β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).
生化/生理作用
Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.
特点和优势
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Vascular endothelial growth factor has beneficial effect independent of serum components throughout oocyte maturation and early embryonic development in cattle
Luo H, et al.
Asian-Australasian Journal of Animal Sciences, 19(4), 495-499 (2006)
ATP-dependent 17-Estradiol 17-(-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP) INHIBITION BY CHOLESTATIC STEROIDS
Loe DW, et al.
The Journal of Biological Chemistry, 271, 9683-9689 (1996)
Vascular endothelial growth factor (VEGF) promotes the early development of bovine embryo in the presence of cumulus cells
Luo H, et al.
The Journal of Veterinary Medical Science, 64(11), 967-971 (2002)
In vitro Glucuronidation of Estradiol-17 beta by Microsomes Prepared using Liver Biopsy Specimens from Dairy Cows
Kadokawa H, et al.
The Journal of Veterinary Medical Science, 69(5), 557-559 (2007)
商品
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