生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
human
技术
flow cytometry: 3-10 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... S100A12(6283)
相关类别
一般描述
EN-RAGE是S100/钙粒蛋白超家族的一员。
免疫原
纯化的，大肠埃希菌衍生的重组人细胞外RAGE结合蛋白。
应用
山羊产生的抗EN-RAGE抗体适用于工作浓度为0.1-0.2μg/mL的蛋白质印迹分析，浓度为5-15μg/mL的免疫组化，浓度为3-10μg/mL/106个细胞的流式细胞仪。
生化/生理作用
该基因编码钙，锌和铜结合蛋白，在调节炎症过程和免疫反应中起重要作用。它通过与晚期糖基化终产物受体（AGER）结合来刺激先天免疫细胞，后者激活MAP激酶和NF-κ-B信号通路，从而导致促炎细胞因子的产生以及细胞粘连分子ICAM1和VCAM1的上调。它还刺激肥大细胞脱颗粒和活化，从而产生趋化因子，组胺和细胞因子，白细胞募集到炎症部位。
外形
从含有5％海藻糖的磷酸盐缓冲生理盐水的0.2μm过滤的溶液中冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Zheng Yang et al.
The Journal of allergy and clinical immunology, 119(1), 106-114 (2007-01-09)
The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products. Because inflammation elicited by S100A12 in vivo had characteristics of mast cell (MC) activation, we aimed to define the mechanism. Various MC
Olga V Moroz et al.
BMC biochemistry, 10, 11-11 (2009-04-24)
Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like
A M Cole et al.
FEBS letters, 504(1-2), 5-10 (2001-08-28)
The human airways are protected from pathogenic colonization by a blanket of fluid impregnated with innate antimicrobial effector molecules. Among several previously uncharacterized components, we isolated a peptide that had activity primarily targeting Gram-negative bacteria. We named the peptide 'calcitermin'
Wei Xing Yan et al.
The Journal of biological chemistry, 283(19), 13035-13043 (2008-02-23)
S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain
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