About This Item
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生物来源
synthetic
质量水平
方案
≥93.5% (HPLC)
95.0-102.0% anhydrous basis (ethanol free based)
表单
powder
储存条件
(Tightly closed. Dry. )
颜色
yellow to yellow-green
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
InChI
1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1
InChI key
HALQELOKLVRWRI-ZVACAFRPSA-N
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一般描述
除了抗菌作用，水合多西环素还可以作为基质金属蛋白酶 (MMP) 的抑制剂，这种酶对结缔组织中胶原蛋白的分解至关重要。对角膜糜烂和类风湿关节炎的研究证明其分别显著降低了 MMP-9 和 MMP-8 水平。这种抑制 MMP 的特性有助于保持胶原蛋白的完整性，防止过度的组织降解和支持组织修复。
在细胞生物学中，水合多西环素影响平滑肌细胞，增强粘连并影响原纤维胶原基质的重组。它对引起疟疾的疟原虫恶性疟原虫顶质体基因表达的作用，为传染病研究增加了一个重要的维度。此外，在大鼠研究中，组织形成的抑制有助于理解组织发育的相关性。
考虑到多西环素对各种细胞过程的多方面影响，水合多西环素在代谢组学研究中也有潜力。在更广泛的生化研究背景下，它的广泛作用使其成为研究分子机制和信号通路的有价值工具。
应用
生化/生理作用
活动频谱：它在体内是一种广谱基质金属蛋白酶抑制剂。
特点和优势
- 适合多种研究应用的高质量抗生素
- 非常适合细胞生物学、代谢组学、生化研究。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
从最新的版本中选择一种：
分析证书(COA)
The name of Product D9891 is Doxycycline hyclate. What does hyclate mean?
Hyclate is the United States Adopted Names (USAN) approved contraction for monohydrochloride hemiethanolate hemihydrate.
What is the solubility of Doxycycline hyclate, Product D9891?
Doxycycline hyclate is soluble in water at up to 50 mg/ml.
How stable is Doxycycline hyclate, Product D9891, in water?
Solutions of doxycycline hyclate are best prepared fresh, but they can be stored at 2-8°C for several days. Solutions also need to be protected from light.
What type of activity does Product D9891, Doxycycline hyclate, exhibit?
Doxycycline is a broad spectrum antibiotic and bacteriostatic agent against gram positive/negative bacteria and it has antiprotozoal activity.
At what concentration should I use D9891, Doxyclycline hyclate, for cell culture?
Doxycycline is often used in culture at a concentration of 0.1-12 μg/ml.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is doxycycline hyclate soluble in DMSO?
According to literature sources, doxycycline hyclate is soluble in DMSO at a concentration of 100 mM.
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Ask a Scientist here.
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