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检测方案
≥98% (HPLC)
形式
solid
溶解性
DMSO: ≥26 mg/mL
储存温度
room temp
InChI
1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
InChI key
XUPZAARQDNSRJB-CULRIWENSA-N
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生化/生理作用
Dothiepin hydrochloride is a tricyclic antidepressant.
Hisham E Abdellatef et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 65(5), 1087-1092 (2006-05-24)
Sensitive spectrophotometric and spectrofluorimetric methods are described for the determination of tramadol, acebutolol and dothiepin (dosulepin) hydrochlorides. The two methods are based on the condensation of the cited drugs with the mixed anhydrides of malonic and acetic acids at 60
Helen Bergen et al.
Journal of affective disorders, 123(1-3), 95-101 (2009-10-30)
Antidepressants are used frequently in non-fatal self-poisoning. There are national guidelines for prescribing antidepressants. There have been few investigations of how non-fatal self-poisoning with antidepressants varies in relation to prescribing and to patient characteristics. A comparative study of the use
Santabhanu Chakrabarti et al.
European journal of pediatrics, 169(1), 113-115 (2009-04-07)
This case highlights the importance of considering drug ingestion when the clinical features at presentation are unusual. To our knowledge, this is the first report of atrial flutter secondary to tricyclic antidepressant (TCA) overdose in a child.
[Transitory acute psychosis with serotoninergic syndrome at the time of an intoxication by dosulepin associated with doxylamine and ethanol].
Hafid Belhadj-Tahar et al.
Therapie, 61(6), 540-543 (2007-03-14)
Soeren Boegevig et al.
Clinical toxicology (Philadelphia, Pa.), 49(4), 337-339 (2011-05-14)
CONTEXT. We report a successful acute reversal of potential life threatening QRS complex widening and prolonged QT interval following dosulepin overdose using intravenous lipid emulsion 20% in an unstable patient. CASE DETAILS. A 36-year-old female following the ingestion of 5.25 g of
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