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About This Item
经验公式（希尔记法）:
C17H14N2
CAS号:
分子量:
246.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
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应用
- 3,3-二吲哚甲烷通过削弱咪喹莫特诱导的银屑病小鼠中IRF-7介导的浆细胞样树突状细胞活化来抑制Th17细胞分化。: 研究表明，3,3-二吲哚甲烷可有效抑制Th17细胞分化，为靶向浆细胞样树突状细胞途径的银屑病治疗提供了一种潜在治疗方法（Rasool et al., 2024）。
- 富含二吲哚甲烷的可食用卷心菜对阿霉素诱导的小鼠心脏毒性的保护作用: 这项研究强调了富含二吲哚甲烷的饮食对小鼠的心脏保护作用，提供了一种减轻常见化疗药物阿霉素的心脏毒性作用的饮食方法（Natesh et al., 2024）。
- 纳米制剂3′-二吲哚甲烷调节乳腺癌症细胞的凋亡、迁移和血管生成。: 对纳米制剂3-二吲哚甲烷的研究表明，它显著影响细胞凋亡、迁移和血管生成，表明了其在癌症靶向治疗中的作用（Harakeh et al., 2024）。
- 作为细胞毒性较低的利什曼原虫拓扑异构酶 IB抑制剂的3,3-二吲哚甲烷N-连接结合糖的设计、合成和生物学评估。: 研究提出了一种合成的3,3-二吲哚甲烷结合糖，该结合糖可作为利什曼原虫拓扑异构酶IB的有效抑制剂，显示出较低的细胞毒性和作为治疗剂的潜力（Kour et al., 2023）。
生化/生理作用
一种天然存在于十字花科吲哚-3-甲醇的植物化学物质的酸催化反应产物。其具有抗肿瘤作用。该衍生物既能直接刺激相对高浓度的细胞凋亡，又能增敏 TRAIL 诱导的人癌细胞凋亡。 DIM 诱导人乳腺癌 MCF-7 细胞 G 1 细胞周期阻滞的机制包括 p21 表达增加。DIM 是一种强的线粒体 H + -atp 酶抑制剂。已在环境友好系统中研究了 DIM 及其衍生物作为新型植物生长促进剂的作用。
警示用语：
Warning
危险分类
Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Xueli Tian et al.
Cancer letters, 448, 20-30 (2019-02-05)
3,3'-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and cabbage. Although DIM has been reported to exhibit anticancer properties against multiple tumor types, the direct target proteins of DIM have not been fully
Yiwei Li et al.
Antioxidants & redox signaling, 19(2), 139-150 (2013-02-09)
Oxidative stress has been mechanistically linked with aging and chronic diseases, including cancer. In fact, oxidative stress status, chronic disease-related inflammation, and cancer occurred in the aging population are tightly correlated. It is well known that the activation of nuclear
Sanjeev Banerjee et al.
Mutation research, 728(1-2), 47-66 (2011-06-28)
Emerging evidence provide credible support in favor of the potential role of bioactive products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts, cauliflower and cabbage. Among many compounds, 3,3'-diindolylmethane (DIM) is generated in the acidic environment of the
K Hempstalk et al.
Journal of dairy science, 98(8), 5262-5273 (2015-06-16)
The ability to accurately predict the conception outcome for a future mating would be of considerable benefit for producers in deciding what mating plan (i.e., expensive semen or less expensive semen) to implement for a given cow. The objective of
Jolanta Natalia Latosińska et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 141-153 (2015-06-13)
Three experimental techniques (1)H-(14)N NQDR, (13)C CP/MAS NMR and X-ray and Density Functional Theory (GGA/BLYP with PBC) and Hirshfeld surfaces were applied for the structure-activity oriented studies of two phyto-antioxidants and anticarcinogens: indole-3-carbinol, I3C, and 3,3'-diindolylmethane, DIM, (its bioactive metabolite).
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