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产品名称
去铁胺 甲磺酸盐, powder, ≥92.5% (TLC)
质量水平
方案
≥92.5% (TLC)
表单
powder
颜色
white to off-white
溶解性
H2O: 50 mg/mL
储存温度
−20°C
SMILES字符串
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
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应用
甲磺酸去铁胺用途
- 可预处理细胞，研究其对细胞活力的影响以及与其他化合物的相互作用()
- 研究对淀粉样蛋白-β(Aβ)诱导的脂质运载蛋白2(Lcn2)生产的影响。()
- 诱导细菌培养物的铁饥饿。()
生化/生理作用
一种铁螯合剂，常用于研究细胞增殖和凋亡。 体外 和 体内 实验均显示其对血管平滑肌细胞具有抗增殖作用，并抑制G1期细胞的增殖。 据报道，它也诱导p53。 通过螯合铁诱导HL-60细胞凋亡。 经过1μM去铁胺处理48小时后，DNA明显断裂。 细胞经0.1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。 一些研究表明，它具有抗氧化性能，并保护细胞免受H2O2诱导的损伤。
一种铁螯合剂，常用于研究细胞增殖和凋亡。据报道，它也诱导p53。
去铁胺被用作一个缺氧模拟物质去稳定低氧诱导因子1 (HIF-1)。 去铁胺通过抑制以HIF-1为靶点的脯氨酰羟化酶(PHDs)降解来稳定HIF-1。 去铁胺的抑制机制可能是通过Fe2+ 与酶活性所需的PHD活性位点的螯合作用而实现的。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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