推荐产品
质量水平
检测方案
≥92.5% (TLC)
形式
powder
颜色
white to off-white
溶解性
H2O: 50 mg/mL
储存温度
−20°C
SMILES字符串
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
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应用
Deferoxamine mesylate salt has been used
- for cell pretreatment to assess its influenceon cell viability and its interactions with other compounds ()
- to study the effect on Lipocalin 2(Lcn2) production triggered by amyloid-β(Aβ). ()
- used to induce iron starvation in bacterial cultures.()
生化/生理作用
一种铁螯合剂,常用于研究细胞增殖和凋亡。 体外 和 体内 实验均显示其对血管平滑肌细胞具有抗增殖作用,并抑制G1期细胞的增殖。 据报道,它也诱导p53。 通过螯合铁诱导HL-60细胞凋亡。 经过1μM去铁胺处理48小时后,DNA明显断裂。 细胞经0.1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。 一些研究表明,它具有抗氧化性能,并保护细胞免受H2O2诱导的损伤。
去铁胺被用作一个缺氧模拟物质去稳定低氧诱导因子1 (HIF-1)。 去铁胺通过抑制以HIF-1为靶点的脯氨酰羟化酶(PHDs)降解来稳定HIF-1。 去铁胺的抑制机制可能是通过Fe2+ 与酶活性所需的PHD活性位点的螯合作用而实现的。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Arteriosclerosis and thrombosis : a journal of vascular biology, 14(2), 299-304 (1994-02-01)
Vascular smooth muscle cell (VSMC) growth is a primary component of accelerated and spontaneous atherosclerosis. Previous studies have shown that iron may be involved in the control of enzymatic activities that modulate DNA synthesis in human cells. In this study
Biodegradable hypoxia biomimicry microspheres for bone tissue regeneration.
Journal of biomaterials applications, 34(7), 1028-1037 (2019-10-28)
Journal of bacteriology, 182(21), 5948-5953 (2000-10-13)
Homologs of the ferric uptake regulator Fur and the iron storage protein ferritin play a central role in maintaining iron homeostasis in bacteria. The gastric pathogen Helicobacter pylori contains an iron-induced prokaryotic ferritin (Pfr) which has been shown to be
PloS one, 9(4), e94156-e94156 (2014-04-17)
Hyaluronidases are a family of enzymes that degrade hyaluronic acid (hyaluronan, HA) and widely used in many fields. A hyaluronidase producing bacteria strain was screened from the air. 16S ribosomal DNA (16S rDNA) analysis indicated that the strain belonged to
Neurochemistry international, 132, 104607-104607 (2019-11-25)
Lipocalin 2 (Lcn2) has been implicated to play a role in various neurodegenerative diseases, and normalizing its overexpression may be of therapeutic potential. Iron chelators were found to reduce Lcn2 levels in certain animal models of CNS injury. Focusing on
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