D9378
3,4-二羟基-D-苯丙氨酸
≥95% (TLC), powder, DOPA enantiomer
别名:
3-(3,4-二羟基苯)-D-丙氨酸, D-3-羟基酪氨酸, D-DOPA
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关于此项目
经验公式（希尔记法）:
C9H11NO4
化学文摘社编号:
分子量:
197.19
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
227-343-0
MDL number:
Beilstein/REAXYS Number:
2417637
产品名称
3,4-二羟基-D-苯丙氨酸, powder, ≥95%
InChI key
WTDRDQBEARUVNC-ZCFIWIBFSA-N
InChI
1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m1/s1
SMILES string
N[C@H](Cc1ccc(O)c(O)c1)C(O)=O
assay
≥95%
form
powder
mp
276-278 °C (lit.)
solubility
1 M HCl: soluble
ethanol: insoluble
storage temp.
−20°C
Quality Level
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相关类别
Application
3,4-二羟基-D-苯丙氨酸(D-DOPA)已作为高效液相色谱法(HPLC)标准品，检测刺毛黎豆的发芽和原生种子粉中的L-DOPA。
Biochem/physiol Actions
3,4-二羟基-D-苯丙氨酸(D-DOPA)是DOPA的对映体，具有抗菌作用。D-DOPA可作为多巴胺合成的前体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tomoya Kawazoe et al.
Chemical record (New York, N.Y.), 7(5), 305-315 (2007-10-10)
The flavoprotein D-amino acid oxidase (DAO) degrades the gliotransmitter D-Ser, a potent activator of N-methyl-D-aspartate-type glutamate receptors. A body of evidence suggests that DAO, together with its activator, G72 protein, may play a key role in the pathophysiology of schizophrenia.
Nan Lu et al.
Electrophoresis (2020-09-20)
This review summarizes recent developments (over the past decade) in the field of microfluidics-based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed.
Mark H Burrell et al.
ACS chemical neuroscience, 6(11), 1802-1812 (2015-09-01)
Tonic dopamine (DA) levels influence the activity of dopaminergic neurons and the dynamics of fast dopaminergic transmission. Although carbon fiber microelectrodes and fast-scan cyclic voltammetry (FSCV) have been extensively used to quantify stimulus-induced release and uptake of DA in vivo
Philipp Hörmann et al.
Cell death discovery, 7(1), 151-151 (2021-07-07)
L-3,4-Dihydroxyphenylalanin (L-DOPA or levodopa) is currently the most used drug to treat symptoms of Parkinson's disease (PD). After crossing the blood-brain barrier, it is enzymatically converted to dopamine by neuronal cells and restores depleted endogenous neurotransmitter levels. L-DOPA is prone
Seppo Parkkila et al.
Bioorganic & medicinal chemistry letters, 16(15), 3955-3959 (2006-05-30)
The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and
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