所有图片(2)
About This Item
经验公式（希尔记法）:
C22H19Br2NO3
CAS号:
分子量:
505.20
Beilstein:
6746312
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98%
表单
solid
储存温度
−20°C
SMILES字符串
CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2
InChI
1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1
InChI key
OWZREIFADZCYQD-NSHGMRRFSA-N
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应用
溴氰菊酯已被用于：
- 通过处理HEK293（人类胚胎肾细胞）Tau-BiFC细胞，研究其作为PP2A/PPP3CA抑制剂的影响
- 研究其对虹鳟鱼的天生免疫力的影响
- 研究其对虎虾斑节对虾分子应激水平的影响
生化/生理作用
溴氰菊酯是一种 Ⅱ 类型半合成除虫菊酯，其作为钙调磷酸酶（蛋白磷酸酶 2B）的强效抑制剂，IC 50 约为 100 pM。这种抑制作用通过引起非突变钙通道长时间保持开放，允许大量 Ca2+ 进入细胞内，从而导致细胞过度兴奋。一些钠通道突变显示如非洲爪蟾卵母细胞的 L993F 突变，显示出对溴氰菊酯的敏感性降低。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
212.0 °F - closed cup
闪点(°C)
100 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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