D9286
乙基对硫磷
≥90%, oil
别名:
O,O-二乙基磷酸对硝基苯酯, 对氧磷, 对硝基苯磷酸二乙酯
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关于此项目
线性分子式:
O2NC6H4OP(O)(OC2H5)2
化学文摘社编号:
分子量:
275.20
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-221-0
Beilstein/REAXYS Number:
1915526
MDL number:
产品名称
乙基对硫磷, ≥90%, oil
InChI key
WYMSBXTXOHUIGT-UHFFFAOYSA-N
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
SMILES string
CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
assay
≥90%
form
oil
color
yellow
refractive index
n20/D 1.51 (lit.)
density
1.274 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... PON1(5444)
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Application
乙基对氧磷被用作对氧磷酶（PON）活性测定的底物。 它还被用作脂肪酶抑制剂，以研究安塞曲匹对体内高密度脂蛋白L3（HDL3）向HDL2的同型转移的影响。
Biochem/physiol Actions
强效不可逆乙酰胆碱酯酶抑制剂
Disclaimer
对空气敏感：在氩气下处理
Physical form
油性液体
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
剧毒化学品
此项目有
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Woudberg NJ, et al.
Lipids in Health and Disease, 17(1), 232-232 (2018)
Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib
Johns DG, et al.
European Journal of Pharmacology, 762, 256-262 (2015)
Elena Grao-Cruces et al.
Biomedicines, 9(11) (2021-11-28)
High-density lipoproteins (HDLs) play an important role in reverse cholesterol transport and present antioxidant properties, among others. In the central nervous system (CNS), there are HDLs, where these lipoproteins could influence brain health. Owing to the new evidence of HDL
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