所有图片(1)
About This Item
经验公式（希尔记法）:
C23H25N5O2 · HCl
CAS号:
分子量:
439.94
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
H2O: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c4ccc(cc4)C#N)cc12
InChI
1S/C23H25N5O2.ClH/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;/h1-6,13,15,26H,7-12,16,24H2;1H
InChI key
ZXENQGQAPOYDOJ-UHFFFAOYSA-N
生化/生理作用
Donitriptan is a potent, selective 5-HT1B/1D agonist.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
V Limmroth et al.
Pain, 92(1-2), 101-106 (2001-04-27)
Calcitonin gene related peptide (CGRP) released from the C-fibers projecting from the trigeminal ganglion to the meninges has been suggested to play a crucial role in the pathophysiology of headache, particularly migraine. In humans it has been shown that CGRP
Hermann Mucke
Expert opinion on investigational drugs, 11(12), 1813-1820 (2002-11-30)
While oral formulations of agonists at the serotonin (5-HT) receptor subdivisions 5-HT(1B/1D)--the "triptan" class of drugs--dominate the market for migraine therapy and while still more triptans are under development, recent research efforts have also explored other pharmacological avenues, which are
Robert Létienne et al.
The Journal of pharmacology and experimental therapeutics, 315(2), 849-857 (2005-07-20)
The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds cannot discriminate whether the decrease of
B Tom et al.
Cephalalgia : an international journal of headache, 22(1), 37-47 (2002-05-08)
We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.16-100 microg kg(-1), i.v.) dose-dependently decreased total carotid blood flow and vascular conductance
Rémon W M van den Broek et al.
European journal of pharmacology, 443(1-3), 125-132 (2002-06-05)
Donitriptan is a potent, high efficacy agonist at 5-HT(1B/1D) receptors. We investigated the contractile effects of donitriptan and sumatriptan on human isolated blood vessels of relevance to therapeutic efficacy in migraine (middle meningeal artery) and coronary adverse events (coronary artery).
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