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D9069

Sigma-Aldrich

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

别名:

(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548

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About This Item

经验公式（希尔记法）:
C25H27NO·HCl
CAS号:
15917-65-4
分子量:
393.95
MDL编号:
MFCD03423594
UNSPSC代码:
12352203
PubChem化学物质编号:
329798889
NACRES:
NA.77

无菌性

non-sterile

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

技术

inhibition assay: suitable

溶解性

DMSO: ≥20 mg/mL

运输

ambient

储存温度

room temp

SMILES字符串

Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3

InChI

1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

InChI key

GMLHJWZEYLTNJW-BJFQDICYSA-N

应用

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.

生化/生理作用

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险声明

H350,H360,H410

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000344629
0000344629
0000258810
0000255684
0000255684

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Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
Hackett AR, et al.
Experimental Neurobiology, 308, 72-79 (2018)
Altin Sula et al.
Molecular cell, 81(6), 1160-1169 (2021-01-28)
Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized. We describe the identification of a previously unidentified receptor site within the NavMs voltage-gated sodium channel. Tamoxifen, an estrogen

商品

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Nuclear Receptors (Steroids)

We offers many products related to Nuclear Receptors (Steroids) for your research needs.

核受体（类固醇）

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Chromatograms

application for HPLC

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