推荐产品
产品名称
DMH1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
light yellow to orange
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3
InChI
1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
InChI key
JMIFGARJSWXZSH-UHFFFAOYSA-N
一般描述
DMH1 刺激人类诱导多能干细胞 (hiPSCs) 的神经发生并抑制肺癌的生长和转移。它阻止细胞自噬反应。
应用
DMH1 已被用于骨形态发生蛋白 (BMP) 抑制。 也被用于阻断血管内皮生长因子 (VEGF) 信号。
生化/生理作用
DMH1 是一种高选择性骨形态发生蛋白 (BMP) 抑制剂。
DMH1 是一种高选择性骨形态发生蛋白 (BMP) 抑制剂。DMH1 是一种 Dorsomorphin 类似物，仅靶向 BMP ，但不是 VEGF 通路。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
Silvia Colucci et al.
Blood, 130(19), 2111-2120 (2017-09-03)
The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP
An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta
Lanza AR, et al.
Developmental Biology, 435(1), 26-40 (2018)
José M Martín-Durán et al.
Nature, 553(7686), 45-50 (2017-12-14)
It has been hypothesized that a condensed nervous system with a medial ventral nerve cord is an ancestral character of Bilateria. The presence of similar dorsoventral molecular patterns along the nerve cords of vertebrates, flies, and an annelid has been
BMP signaling is required for nkx2. 3-positive pharyngeal pouch progenitor specification in zebrafish
Li Linwei, et al.
PLoS Genetics, 15(2), e1007996-e1007996 (2019)
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