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Merck
CN

D8190

3′,4′-二氯苯甲酰胺 盐酸盐

>98% (HPLC)

别名:

L-594,881

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关于此项目

经验公式(希尔记法):
C13H12N7OCl3 · HCl
化学文摘社编号:
分子量:
425.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI key

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

SMILES string

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

assay

>98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble 30 mg/mL, H2O: insoluble

storage temp.

2-8°C

Quality Level

Biochem/physiol Actions

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig.
Ricardo Espinosa-Tanguma
Journal of muscle research and cell motility, 25(8), 620-621 (2005-08-25)
G H Liang et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60(1), 43-50 (2009-05-15)
We investigated the effects of the selective inhibitor of Na(+)/Ca(2+) exchanger (NCX), 2',4'- and 3',4'-dichlorobenzamil (DCB), on large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in cultured human umbilical vein endothelial cells (HUVECs) and fresh isolated mouse aortic smooth muscle cells (MASMCs) using
Hardeep Kaur et al.
Biological & pharmaceutical bulletin, 33(4), 585-591 (2010-04-23)
The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with
D Taubert et al.
Diabetologia, 47(12), 2059-2071 (2005-01-22)
Chronic exposure to high concentrations of glucose has consistently been demonstrated to impair endothelium-dependent, nitric oxide (NO)-mediated vasodilation. In contrast, several clinical investigations have reported that acute exposure to high glucose, alone or in combination with insulin, triggers vasodilation. The
J P Danaceau et al.
The Journal of general physiology, 115(6), 759-768 (2000-06-01)
Olfactory receptor neurons (ORNs) from the squid, Lolliguncula brevis, respond to the odors l-glutamate or dopamine with increases in internal Ca(2+) concentrations ([Ca(2+)](i)). To directly asses the effects of increasing [Ca(2+)](i) in perforated-patched squid ORNs, we applied 10 mM caffeine

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