D8190
3′,4′-二氯苯甲酰胺 盐酸盐
>98% (HPLC)
别名:
L-594,881
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关于此项目
经验公式（希尔记法）:
C13H12N7OCl3 · HCl
化学文摘社编号:
分子量:
425.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
LPHAOBPPRPXQLQ-UHFFFAOYSA-N
SMILES string
NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl
InChI
1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H
assay
>98% (HPLC)
form
solid
color
yellow
solubility
DMSO: soluble 30 mg/mL, H2O: insoluble
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A S Arbab et al.
Nuclear medicine communications, 24(2), 155-166 (2003-01-28)
Our aim was to determine whether the Ca2+ ion or cell membrane Ca2+ and Na+/Ca2+ ion transport systems are involved in maintaining the cell-associated activity of technetium-99m-hexakis-methoxy-isobutyl-isonitrile (99mTc-MIBI) and technetium-99m-ethylene-bis[bis(2-ethoxyethyl)phosphin] (99mTc-tetrofosmin) in tumour cell lines. The cell-associated activities of 99mTc-MIBI
C Soto et al.
The Journal of experimental zoology, 289(1), 23-32 (2001-02-13)
The aim of this study was to analyze the relationship of the Na+/Ca2+ exchanger, cytosolic calcium, and chloride to the transepithelial transport of sodium in isolated frog skin. Sodium transport was measured as amiloride-inhibitable short circuit current (SCC). We studied
Shaminder Kaur et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(4), 435-443 (2009-04-02)
The present study was designed to investigate the possible neuroprotective effect of digoxin induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral carotid artery occlusion (BCAO) of 17 min followed by reperfusion for 24 h was employed to produce ischemia
G H Liang et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60(1), 43-50 (2009-05-15)
We investigated the effects of the selective inhibitor of Na(+)/Ca(2+) exchanger (NCX), 2',4'- and 3',4'-dichlorobenzamil (DCB), on large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in cultured human umbilical vein endothelial cells (HUVECs) and fresh isolated mouse aortic smooth muscle cells (MASMCs) using
Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig.
Ricardo Espinosa-Tanguma
Journal of muscle research and cell motility, 25(8), 620-621 (2005-08-25)
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