D8174
9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α
≥98% (HPLC), solution, thromboxane A2 agonist
别名:
U-46619, U46619
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关于此项目
经验公式（希尔记法）:
C21H34O4
化学文摘社编号:
分子量:
350.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Beilstein/REAXYS Number:
4267334
产品名称
9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α, solution, 10 mg/mL in methyl acetate
InChI
1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
SMILES string
CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
InChI key
LQANGKSBLPMBTJ-REGKDVDGSA-N
form
solution
concentration
10 mg/mL in methyl acetate
shipped in
dry ice
storage temp.
−20°C
Quality Level
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相关类别
Application
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α已用于：
- 诱导肌球蛋白轻链9（Myl9）基因缺失的小鼠的主动脉平滑肌（SM）收缩
- 诱导收缩作为小鼠主动脉血管反应性实验的一部分
- 作为血栓素/前列腺激动剂，以研究二硫苏糖醇（DTT）对小鼠动脉血管活性的影响
Biochem/physiol Actions
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种血栓素A2激动剂。它可在体外实验中诱导血小板的形状变化、凝集、分泌、磷酸肌醇水解和蛋白质磷酸化。它还会引起胞质Ca++水平的升高，轻微影响环磷酸腺苷（cAMP）的形成。它可用作血管细胞粘附分子-1（VCAM-1）的有效刺激因子，以介导白细胞粘附至内皮细胞。
General description
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种内过氧化物/血栓素类似物。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
14.0 °F
flash_point_c
-10 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
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