D7911
癸基泛醌
≥97% (HPLC)
别名:
2,3-二甲氧基-5-甲基-6-癸基-1,4-苯醌
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关于此项目
经验公式（希尔记法）:
C19H30O4
化学文摘社编号:
分子量:
322.44
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12162212
MDL number:
产品名称
癸基泛醌, ≥97% (HPLC)
InChI
1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3
SMILES string
CCCCCCCCCCC1=C(C)C(=O)C(OC)=C(OC)C1=O
InChI key
VMEGFMNVSYVVOM-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
liquid
storage temp.
−20°C
Quality Level
Application
- 作为钯诱导脂肪毒性中介物的溶酶体钙（2+）。: 该研究探索了癸基泛醌（decylubiquinone）在调节溶酶体钙（2+）水平中的作用，提供了有关脂肪毒性机制和代谢疾病潜在治疗应用的见解（Oh et al., 2023）。
- VI型硫化物中的醌结合位点:醌氧化还原酶。：该论文研究了癸基泛醌在硫化物:醌氧化还原酶中的结合动力学,阐明了其在微生物呼吸中的作用和潜在生物技术应用（Miklovics et al., 2022）。
- 癸基泛醌对B16F10诱导小鼠中继发性黑色素瘤的保护作用。: 该研究展示了癸基泛醌在黑色素瘤小鼠模型中的抗转移性质，重点介绍了其成为癌症治疗中治疗药的潜力（Chatterjee et al., 2023）。
- 癸基泛醌通过上调Sirtuin2来抑制结肠直肠癌细胞生长。: 该研究确认了癸基泛醌是通过调节Sirtuin2表达，而成为结肠直肠癌细胞生长的抑制剂，研究暗示了其在癌症治疗中的应用（Li et al., 2021）。
General description
泛醌类似物。
线粒体通透性转换孔 (MPTP) 抑制剂。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Pamela David et al.
Biochimica et biophysica acta, 1553(3), 268-278 (2002-05-09)
The NADH:ubiquinone oxidoreductase (NDH-1 or Complex I) of Escherichia coli is a smaller version of the mitochondrial enzyme, being composed of 13 protein subunits in comparison to the 43 of bovine heart complex I. The bacterial NDH-1 from an NDH-2-deficient
Jeffrey S Armstrong et al.
The Journal of biological chemistry, 278(49), 49079-49084 (2003-09-02)
The mitochondrial permeability transition (MPT) is a key event in apoptotic and necrotic cell death and is controlled by the cellular redox state. To further investigate the mechanism(s) involved in regulation of the MPT, we used diethylmaleate to deplete GSH
Hongzhi Li et al.
Biochimica et biophysica acta, 1863(9), 2266-2273 (2017-06-01)
Our previous study generated a series of cybrids containing mitochondria of synaptosomes from mice at different ages. The following functional analysis on these cybrids revealed an age-dependent decline of mitochondrial function. To understand the underlying mechanisms that contribute to the
Yasser Ahmed Mahmmoud et al.
The Journal of biological chemistry, 280(30), 27776-27782 (2005-05-28)
FXYD domain-containing proteins are tissue-specific regulators of the Na,K-ATPase that have been shown to have significant physiological implications. Information about the sites of interaction between some FXYD proteins and subunits of the Na,K-ATPase is beginning to emerge. We previously identified
Zeqi Zheng et al.
International journal of nanomedicine, 15, 4501-4521 (2020-07-02)
Elevation of blood homocysteine (Hcy) level (hyperhomocysteinemia) is a risk factor for cardiovascular disorders and is closely associated with endothelial dysfunction. The present study aims to investigate the protective effect and underlying mechanism of nanoscale selenium (Nano-Se) in Hcy-mediated vascular
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