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Merck
CN

D7910

Sigma-Aldrich

3,4-二氯异香豆素

serine protease inhibitor

别名:

3,4-DCI, 3,4-二氯-2-苯并吡喃-1-酮

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About This Item

经验公式(希尔记法):
C9H4Cl2O2
CAS号:
分子量:
215.03
Beilstein:
6802625
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (TLC)

形式

powder

溶解性

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

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相关类别

应用

可用于巨噬细胞的快速染色鉴定;通过更复杂的形态学标准、吞噬作用和 Fc 受体的存在证实了该方法的计数。

其他说明

有效浓度为 5-100μM。

数量

PH 7.5 时半衰期 = 20 分钟。

底物

丝氨酸蛋白酶抑制剂。对包括颗粒酶内部的多种丝氨酸蛋白酶具有活性。对β-内酰胺酶无活性。

象形图

Skull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Anežka Tichá et al.
Cell chemical biology, 24(12), 1523-1536 (2017-11-07)
Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped. Here, we
Premkumari Kumarathasan et al.
Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)
There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a
Diego López León et al.
iScience, 23(3), 100932-100932 (2020-03-11)
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show
Brett M Babin et al.
Cell chemical biology, 29(5), 897-909 (2021-10-03)
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope.
K S Lang et al.
Cell death and differentiation, 11(2), 231-243 (2003-11-15)
Erythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following increase of cytosolic Ca(2+) activity, erythrocytes undergo cell shrinkage, cell membrane blebbing and breakdown of phosphatidylserine asymmetry, all features typical for apoptosis in nucleated cells.

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