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Merck
CN

D7816

Sigma-Aldrich

1,2-二-O-月桂基-rac-甘油-3-戊二酸-6′-甲基雷洛芬酯

lipase substrate

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别名:
Chromogenic lipase substrate
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32

质量水平

形式

solid

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCOCC(COC(=O)CCCC(=O)Oc1ccc2N=C3C=CC(=O)C=C3Oc2c1C)OCCCCCCCCCCCC

InChI

1S/C45H69NO8/c1-4-6-8-10-12-14-16-18-20-22-31-50-34-38(51-32-23-21-19-17-15-13-11-9-7-5-2)35-52-43(48)25-24-26-44(49)53-41-30-29-40-45(36(41)3)54-42-33-37(47)27-28-39(42)46-40/h27-30,33,38H,4-26,31-32,34-35H2,1-3H3

InChI key

JEGLJLCZRAWOBI-UHFFFAOYSA-N

应用

用于脂肪酶的显色底物

生化/生理作用

1,2-二-O-月桂基-rac-甘油-3-戊二酸-6′-甲基雷洛芬酯(DGGR)具有更强的胰腺特异性。因此DGGR脂肪酶最好是作为spec cPL的替代品,用于疑似胰腺炎诊断病例中。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Validation of a commercial 1, 2-o-dilauryl-rac-glycero glutaric acid-(6?-methylresorufin) ester lipase assay for diagnosis of canine pancreatitis
Goodband E L, et al.
Veterinary record open, 5(1), e000270-e000270 (2018)
Breanne M Coady et al.
Journal of peptide science : an official publication of the European Peptide Society, 24(11), e3123-e3123 (2018-10-06)
Human hepatic lipase (hHL) is a cell surface associated enzyme that hydrolyzes triacylglycerols and phospholipids within circulating lipoproteins. We hypothesized that an amino acid sequence mimicking the major heparin binding domain (HBD) of hHL will displace hHL from cell surfaces.
Narmadaa Thyagarajan et al.
Lipids, 52(3), 189-205 (2017-02-17)
Macrophage lipoprotein lipase (LPL) induces lipid accumulation and promotes atherosclerosis. However, the effects of lipoprotein hydrolysis products generated by LPL on macrophage-derived foam cell formation are not clearly understood. Thus, we analyzed the transcriptomic response to hydrolysis products via microarray

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