D7815
R(−)-Denopamine
≥98% (HPLC), β1 adrenoceptor agonist, powder
别名:
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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关于此项目
经验公式（希尔记法）:
C18H23NO4
化学文摘社编号:
分子量:
317.38
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
R(−)-Denopamine, ≥98% (HPLC), powder
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear, H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB1(153)
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Biochem/physiol Actions
β1-adrenoceptor agonist.
Denopamine is a cardiotonic drug.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Light sensitive.
T Sakuma et al.
Japanese journal of pharmacology, 85(2), 161-166 (2001-04-05)
Because it was still uncertain whether a stimulation of beta1-adrenoceptors accelerated alveolar fluid clearance in hyperoxic lung injury, the effect of denopamine, a selective beta1-adrenergic agonist, on alveolar fluid clearance was determined in rats exposed to 93% oxygen for 48
Weak arrhythmogenic property of the new cardiotonic agent denopamine in dogs: comparison with catecholamines
NARITA H, et al.
Japanese Journal of Pharmacology, 41(3), 335-344 (1986)
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
T Bando et al.
Oncology reports, 7(1), 49-52 (1999-12-22)
Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it
A Marcantoni et al.
Pflugers Archiv : European journal of physiology, 457(5), 1093-1110 (2008-09-10)
We studied the effects of the cAMP-hydrolyzing enzyme phosphodiesterase type-4 (PDE4) on the L-type Ca(2+) channels (LTCCs) and Ca(2+)-dependent secretion in mouse chromaffin cells (MCCs). The selective PDE4 inhibitor rolipram (3 microM) had a specific potentiating action on Ca(2+) currents
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