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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: 10 mg/mL, clear
H2O: insoluble
储存温度
2-8°C
SMILES字符串
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
基因信息
human ... ADRB1(153)
应用
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
生化/生理作用
β1-adrenoceptor agonist.
Denopamine is a cardiotonic drug.
特点和优势
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
光敏。
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions
Bachmann SB, et al.
Testing, 27(11), 3305-3314 (2019)
T Bando et al.
Oncology reports, 7(1), 49-52 (1999-12-22)
Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it
Hidefumi Kaji et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(3), 403-412 (2004-12-21)
Denopamine is one of the oral beta(1)-adrenoceptor-selective partial agonists. Denopamine glucuronide is the most abundant metabolite in human, rat, and dog urine when administered orally. Species differences in denopamine glucuronidation were investigated with liver microsomes obtained from humans and experimental
S Chiba et al.
Journal of autonomic pharmacology, 21(1), 7-13 (2001-06-26)
1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilation in preparations preconstricted by phenylephrine in a dose-related
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
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