D7696
去甲氧基姜黄素
≥98% (HPLC), powder, LPS-induced nitric oxide (NO) production inhibitor
别名:
(E,E)1-（4-羟基-3-甲氧基苯基）-7-（4-羟基苯基）-1,6-庚二烯-3,5-二酮, 单脱甲氧基姜黄素, 去甲氧基姜黄素, 姜黄素 II
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关于此项目
经验公式（希尔记法）:
C20H18O5
化学文摘社编号:
分子量:
338.35
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
去甲氧基姜黄素, ≥98% (HPLC)
SMILES string
COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)ccc1O
InChI key
HJTVQHVGMGKONQ-LUZURFALSA-N
InChI
1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
orange
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
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相关类别
Biochem/physiol Actions
脱甲氧基姜黄素 (DMC) 是一种衍生物或姜黄素，是从 姜黄中分离得到的姜黄素产品的主要活性成分之一。DMC通过阻止NF-kB激活来抑制LPS诱导的一氧化氮（NO）产生以及RAW264.7细胞中iNOS和COX2的表达。在LPS处理的大鼠小胶质细胞中，DMC也抑制NF-kB对iNOS，TNFα和IL-1β的表达。DMC通过抑制NF-kB抑制MDA-MB-231人乳腺癌细胞中MMP和ICAM-1的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lijia Zhang et al.
International immunopharmacology, 10(3), 331-338 (2009-12-19)
Our previous report has showed that demethoxycurcumin (DMC), a natural derivative of curcumin (Cur), exhibited stronger inhibitory activity on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production compared with Cur in lipopolysaccharide (LPS) activated rat primary microglia. In the
Hye Jin Kim et al.
Phytochemical analysis : PCA, 20(5), 372-377 (2009-06-18)
The new ion source technique, direct analysis in real time (DART) atmospheric pressure ionisation, allows high resolution mass measurements of gas, liquid and solid samples. As DART-MS produces [M + H](+) molecular ions of most compounds, relatively simple and clear
T Ahmed et al.
Neuroscience, 169(3), 1296-1306 (2010-06-12)
Alzheimer's disease (AD) is a neurodegenerative disease. There are a limited number of therapeutic options available for the treatment of AD. Curcuminoids (a mixture of bisdemethoxycurcumin, demethoxycurcumin and curcumin) is the main chemical constituent found in turmeric, a well known
Supachai Yodkeeree et al.
European journal of pharmacology, 627(1-3), 8-15 (2009-10-13)
Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer
R Douglas Shytle et al.
Current Alzheimer research, 6(6), 564-571 (2009-09-01)
Inhibition of beta-amyloid (A beta) accumulation and A beta fibril (fA beta) formation from A beta are attractive therapeutic targets for the treatment of Alzheimer's disease (AD). While previous studies have shown anti-amyloidogenic effects of curcumin in vitro and in
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