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Merck
CN

D7693

Sigma-Aldrich

Dynasore 水合物

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

别名:

3-羟基-萘-2-羧酸(3,4-二羟基-亚苄基)-酰肼 水合物

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About This Item

经验公式(希尔记法):
C18H14N2O4 · xH2O
分子量:
322.31 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

product name

Dynasore 水合物,

形式

powder

质量水平

储存条件

protect from light

颜色

off-white

溶解性

DMSO: ≥10 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES字符串

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

InChI key

FKWZHQSDBMSHTN-ZIOFAICLSA-N

一般描述

Dynasore是一种小分子GTP酶抑制剂,其可靶向发动蛋白-1、发动蛋白-2和Drp1(线粒体)。Dynasore可阻断发动蛋白依赖的内吞作用,以及内吞囊泡的断裂。Dynosore是促纤维化的,可在胸膜间皮细胞中诱导PAI-1,且可能成为有效的胸膜固定剂。Dynasor可阻断人乳头瘤病毒16型(HPV16)和牛乳头瘤病毒1型(BPV1)(假病毒粒子)的感染。
Dynasore水合物可降低质膜中的不稳定胆固醇水平并破坏脂筏组织。Dynasore对单纯疱疹病毒(HSV)-1和HSV-2感染具有多效性。它阻碍了病毒进入、病毒蛋白的运输和衣壳的形成。

应用

Dynasore水合物已被用于:
  • 引发胎儿间充质干/基质细胞(fMSC)
  • 共聚焦显微镜检测
  • 伤口愈合/划痕和管形成测定
  • 分析其对柯萨奇病毒A9(CAV9)感染的影响
  • 抑制网格蛋白介导的内吞作用和小窝蛋白介导的内吞作用
  • 细胞的实时成像

生化/生理作用

Dynasore是一种细胞渗透性、可逆的非竞争性发动蛋白1和发动蛋白2的GTP酶活性抑制剂。

特点和优势

该化合物是环核苷酸研究的推荐产品。点击此处,了解更多精选环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm

象形图

Environment

警示用语:

Warning

危险声明

预防措施声明

危险分类

Aquatic Acute 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves


分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How can I store a solution of Product D7693, Dynasore hydrate?

    We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use.  We recommend storing at -20°C in single use aliquots.

  6. What can I use to make a solution of Product D7693, Dynasore hydrate?

    As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL.  It is also soluble in ethanol at 1 mg/mL.  

  7. What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?

    The following reference uses Dynasore at 80 μM:  Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.  Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells
Pelekanos RA, et al.
BMC Cell Biology, 15(1), 15-15 (2014)
Dynasore-not just a dynamin inhibitor
Preta G, et al.
Cell communication and signaling : CCS, 13(1), 24-24 (2015)
Florian Ehlgen et al.
PloS one, 7(6), e38781-e38781 (2012-06-22)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane
G J Hofmeyr et al.
BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)
Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in
Tom Kirchhausen et al.
Methods in enzymology, 438, 77-93 (2008-04-17)
The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for

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