所有图片(1)
别名:
4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
经验公式（希尔记法）:
C16H16ClNO4S
推荐产品
质量水平
检测方案
>98% (HPLC)
形式
solid
颜色
white
mp
132.5-137.4 °C (lit.)
溶解性
DMSO: soluble 22 mg/mL
SMILES字符串
OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI
1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
InChI key
IULOBWFWYDMECP-UHFFFAOYSA-N
基因信息
human ... TBXA2R(6915)
一般描述
Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.
生化/生理作用
Selective thromboxane A2 receptor antagonist
特点和优势
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
T Tanaka et al.
European journal of pharmacology, 357(1), 53-60 (1998-10-27)
We investigated the pharmacological characteristics of Z-335 ((+/-)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]ace tate monohydrate), a new indan derivative. Z-335 inhibited the specific binding of [3H]SQ-29548 to human platelets and guinea pig platelet membranes. The IC50 values of Z-335 for human platelets and guinea pig
U Grandel et al.
Circulation, 102(22), 2758-2764 (2000-11-30)
Although endotoxin (lipopolysaccharides, LPS) is recognized as a mediator of septic cardiodepression, its cardiac effects are still not fully elucidated. Perfusion of isolated rat hearts with LPS for 180 minutes resulted in a decline of left ventricular contractility after 90
Growth inhibitory effects of thromboxane antagonists on breast cancer cell lines: a preliminary study.
K Marshall et al.
Advances in experimental medicine and biology, 400A, 455-460 (1997-01-01)
Anna K Leal et al.
American journal of physiology. Heart and circulatory physiology, 301(5), H2140-H2146 (2011-08-23)
Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstitium are increased by exercise
D Walmrath et al.
American journal of respiratory and critical care medicine, 154(2 Pt 1), 460-468 (1996-08-01)
Both endotoxin (lipopolysaccharides of gram-negative bacteria; LPS) and bacterial exotoxins may induce pulmonary microcirculatory disturbances when infused into the lung vasculature, and synergism between these types of microbial challenge has recently been noted. We now asked whether a bronchoalveolar LPS
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