D7441
Daltroban
>98% (HPLC)
别名:
4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
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关于此项目
经验公式（希尔记法）:
C16H16ClNO4S
化学文摘社编号:
分子量:
353.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
IULOBWFWYDMECP-UHFFFAOYSA-N
SMILES string
OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI
1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
assay
>98% (HPLC)
form
solid
color
white
mp
132.5-137.4 °C (lit.)
solubility
DMSO: soluble 22 mg/mL
Quality Level
Gene Information
human ... TBXA2R(6915)
General description
Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.
Biochem/physiol Actions
Selective thromboxane A2 receptor antagonist
Features and Benefits
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
M Rathaus et al.
Clinical science (London, England : 1979), 88(6), 623-627 (1995-06-01)
1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase in the glomerular thromboxane B2-prostaglandin E2 ratio. 2. To
Sabine Pestel et al.
Biochemical pharmacology, 66(4), 643-652 (2003-08-09)
Prostanoids, i.e. prostaglandins and thromboxane, regulate liver-specific functions both in homeostasis and during defense reactions. For example, prostanoids are released from Kupffer cells, the resident liver macrophages, in response to the inflammatory mediator anaphylatoxin C5a, and mediate an enhanced glucose
Growth inhibitory effects of thromboxane antagonists on breast cancer cell lines: a preliminary study.
K Marshall et al.
Advances in experimental medicine and biology, 400A, 455-460 (1997-01-01)
U Grandel et al.
Circulation, 102(22), 2758-2764 (2000-11-30)
Although endotoxin (lipopolysaccharides, LPS) is recognized as a mediator of septic cardiodepression, its cardiac effects are still not fully elucidated. Perfusion of isolated rat hearts with LPS for 180 minutes resulted in a decline of left ventricular contractility after 90
T Tanaka et al.
European journal of pharmacology, 357(1), 53-60 (1998-10-27)
We investigated the pharmacological characteristics of Z-335 ((+/-)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]ace tate monohydrate), a new indan derivative. Z-335 inhibited the specific binding of [3H]SQ-29548 to human platelets and guinea pig platelet membranes. The IC50 values of Z-335 for human platelets and guinea pig
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