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Merck
CN

D7159

Sigma-Aldrich

2′,3′-二脱氧胞苷 5′-三磷酸 钠盐

≥90% (HPLC)

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别名:
ddCTP
经验公式(希尔记法):
C9H16N3O12P3
分子量:
451.16
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:

生物来源

synthetic (organic)

检测方案

≥90% (HPLC)

形式

powder

溶解性

water: 1 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

[Na+].NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2

InChI

1S/C9H16N3O12P3.Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16;/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16);/q;+1/p-1/t6-,8+;/m0./s1

InChI key

LOOMQRBEBYCFPP-QDOHZIMISA-M

应用

通过X射线晶体学研究了ddCTP与DNA聚合酶β的复合物,对HIV逆转录酶的抑制活性有影响。

生化/生理作用

DNA 聚合酶 I 催化的链延伸抑制剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex
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