D6946
(R)-DRF053 hydrochloride hydrate
≥98% (HPLC)
别名:
2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C23H27N7O · xHCl · yH2O
分子量:
417.51 (anhydrous free base basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow
溶解性
DMSO: ≥30 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1
InChI
1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1
InChI key
ZOSNTFVWVJFXQO-ZEECNFPPSA-N
生化/生理作用
DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).
特点和优势
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mikołaj Słabicki et al.
Nature, 585(7824), 293-297 (2020-06-05)
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid depletion of previously inaccessible targets2. They are clinically
商品
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
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