所有图片(2)
About This Item
经验公式（希尔记法）:
C28H38N2O5 · HCl
CAS号:
分子量:
519.07
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: ~20 mg/mL
储存温度
2-8°C
SMILES字符串
O=C1CC2=CC(OC)=C(OC)C=C2CCN1C[C@@H](CCC3)CN3CCC4=CC(OC)=C(OC)C=C4.[H]Cl
InChI
1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3;1H/t21-;/m0./s1
InChI key
MTAKUIYCCYKGJJ-BOXHHOBZSA-N
应用
DK-AH 269 has been used as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist to study its effects on the inhibition of Ih in HCN-deficient hair cells of mice. It has also been used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons.
生化/生理作用
DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
DK-AH 269 is a bradycardiac agent.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus
Atkinson S E, et al.
Journal of biological rhythms, 26(3), 210-220 (2011)
Effects of a bradycardic agent (DK-AH 269) on haemodynamics and oxygen consumption of isolated blood-perfused rabbit hearts
Granetzny A, et al.
Journal of Clinical and Basic Cardiology, 3(3), 191-196 (2000)
Specific bradycardic agents block the hyperpolarization-activated cation current in central neurons.
H C Pape
Neuroscience, 59(2), 363-373 (1994-03-01)
A class of pharmacologically active substances, known as "specific bradycardic agents", exerts a negative chronotropic influence on cardiac activity, which heavily relies upon a potent blockade of the hyperpolarization-activated cation current in Purkinje fibers. Since the cation conductance activated by
HCN channels expressed in the inner ear are necessary for normal balance function
Horwitz G C, et al.
The Journal of Neuroscience, 31(46), 16814-16825 (2011)
A Raes et al.
British journal of pharmacology, 125(4), 741-750 (1998-12-01)
1. The sinus node inhibitors UL FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a hyperpolarization-activated current If. A hyperpolarization-activated current Ih
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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