所有图片(1)
About This Item
经验公式（希尔记法）:
C17H14O4
CAS号:
分子量:
282.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
方案
≥98% (HPLC)
质量水平
表单
powder
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
储存温度
room temp
SMILES字符串
COc1ccc(cc1OC)C2=CC(=O)c3ccccc3O2
InChI
1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
InChI key
ZGHORMOOTZTQFL-UHFFFAOYSA-N
应用
3′,4′-二甲氧基黄酮已被用于脲酶抑制试验。
生化/生理作用
3′,4′-二甲氧基黄酮是AhR的竞争性拮抗剂，其可抑制AhR介导的CYP1A1诱导，并且还在乳腺肿瘤细胞系中显示出抗雌激素活性。该化合物可阻断细胞溶质AhR复合物的转化，并形成核AhR复合物。
3′,4′-二甲氧基黄酮是一种黄酮化合物，其具有防止聚（ADP-核糖）（PAR）聚合物的产生和积累的能力。它可在皮质神经元中防御 N-甲基-D-天冬氨酸（NMDA）的毒性。3′,4′-二甲氧基黄酮是植物来源的多酚类黄酮类的成员。已知它具有抗氧化、抗癌、抗炎、抗动脉粥样硬化、降血脂和神经保护或神经营养作用。
3′,4′-二甲氧基黄酮是芳香烃受体（AhR）的竞争性拮抗剂，其可抑制AhR介导的CYP1A1诱导，并且还在乳腺肿瘤细胞系中显示出抗雌激素活性。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Flavonoids as natural inhibitors of jack bean urease Enzyme
AJ Awllia, et al.
Letters in Drug Design & Discovery, 13(3), 243-249 (2016)
Identification through high-throughput screening of 4'-methoxyflavone and 3', 4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
Fatokun AA, et al.
British Journal of Pharmacology, 169(6), 1263-1278 (2013)
Nada H Eisa et al.
International journal of molecular sciences, 21(21) (2020-10-30)
There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported
Dan J M Nguyen et al.
Molecular cancer research : MCR, 18(1), 105-117 (2019-10-20)
Cisplatin resistance is a major barrier in the effective treatment of lung cancer. Cisplatin-resistant (CR) lung cancer cells do not primarily use glucose but rather consume amino acids such as glutamine and tryptophan (Trp) for survival. CR cells activate the
Ke Wang et al.
International journal of molecular sciences, 16(7), 16454-16468 (2015-07-25)
Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门